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Cell Signal Transduction Research Antibodies
Synuclein-γ Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight13331 DaObserved Band:20 KD
Protein NameGamma-synuclein
Human Gene Id6623
Human Swiss Prot NoO76070
Mouse Swiss Prot NoQ9Z0F7
SpecificitySynuclein-γ Polyclonal Antibody detects endogenous levels of Synuclein-γ protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameSNCG; BCSG1; PERSYN; PRSN; Gamma-synuclein; Breast cancer-specific gene 1 protein; Persyn; Synoretin; SR
Functiondisease:Brain iron accumulation type 1 (NBIA1, also called Hallervorden-Spatz syndrome), a rare neuroaxonal dystrophy, is histologically characterized by axonal spheroids, iron deposition, Lewy body (LB)-like intraneuronal inclusions, glial inclusions and neurofibrillary tangles. SNCG is found in spheroids but not in inclusions.,function:Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway.,PTM:Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases.,similarity:Belongs to the synuclein family.,subcellular location:As
Subcellular LocationCytoplasm, perinuclear region . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle . Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle.
ExpressionHighly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human Synuclein gamma. AA range:78-127
Gene NameSNCG
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Backgroundsynuclein gamma(SNCG) Homo sapiens This gene encodes a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. Mutations in this gene have also been associated with breast tumor development. [provided by RefSeq, Jan 2010],
Conjugated Antibody
This product is also available conjugated. Format: E20-74499-Conjugate. Price: $485 / Size: 100μl.
E20-74499-FITC$485 / 100μlE20-74499-Biotin$485 / 100μlE20-74499-HRP$485 / 100μlE20-74499-AP$485 / 100μlE20-74499-AF350$485 / 100μlE20-74499-AF405M$485 / 100μlE20-74499-AF488$485 / 100μlE20-74499-AF514$485 / 100μlE20-74499-AF532$485 / 100μlE20-74499-AF555$485 / 100μlE20-74499-AF568$485 / 100μlE20-74499-AF405S$485 / 100μlE20-74499-AF405L$485 / 100μlE20-74499-AF546$485 / 100μlE20-74499-AF594$485 / 100μlE20-74499-AF610$485 / 100μlE20-74499-AF635$485 / 100μlE20-74499-AF647$485 / 100μlE20-74499-AF680$485 / 100μlE20-74499-AF700$485 / 100μlE20-74499-AF750$485 / 100μlE20-74499-AF790$485 / 100μlE20-74499-APC$485 / 100μlE20-74499-PE$485 / 100μlE20-74499-Cy3$485 / 100μlE20-74499-Cy5$485 / 100μlE20-74499-Cy5.5$485 / 100μlE20-74499-Cy7$485 / 100μlE20-74499-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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