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Cell Signal Transduction Research Antibodies
Synuclein-β Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight14288 DaObserved Band:14 KD
Protein NameBeta-synuclein
Human Gene Id6620
Human Swiss Prot NoQ16143
Mouse Gene Id104069
Mouse Swiss Prot NoQ91ZZ3
Rat Gene Id113893
Rat Swiss Prot NoQ63754
SpecificitySynuclein-β Polyclonal Antibody detects endogenous levels of Synuclein-β protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameSNCB; Beta-synuclein
Functiondisease:Brain iron accumulation type 1 (NBIA1, also called Hallervorden-Spatz syndrome), a rare neuroaxonal dystrophy, is histologically characterized by axonal spheroids, iron deposition, Lewy body (LB)-like intraneuronal inclusions, glial inclusions and neurofibrillary tangles. SNCB is found in spheroids but not in inclusions.,function:Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a TP53/p53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.,PTM:Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.,similarity:Belongs
Subcellular LocationCytoplasm.
ExpressionExpressed predominantly in brain; concentrated in presynaptic nerve terminals.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human Synuclein beta. AA range:85-134
Gene NameSNCB
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Backgroundsynuclein beta(SNCB) Homo sapiens This gene encodes a member of a small family of proteins that inhibit phospholipase D2 and may function in neuronal plasticity. The encoded protein is abundant in lesions of patients with Alzheimer disease. A mutation in this gene was found in individuals with dementia with Lewy bodies. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015],
Conjugated Antibody
This product is also available conjugated. Format: E20-74498-Conjugate. Price: $485 / Size: 100μl.
E20-74498-FITC$485 / 100μlE20-74498-Biotin$485 / 100μlE20-74498-HRP$485 / 100μlE20-74498-AP$485 / 100μlE20-74498-AF350$485 / 100μlE20-74498-AF405M$485 / 100μlE20-74498-AF488$485 / 100μlE20-74498-AF514$485 / 100μlE20-74498-AF532$485 / 100μlE20-74498-AF555$485 / 100μlE20-74498-AF568$485 / 100μlE20-74498-AF405S$485 / 100μlE20-74498-AF405L$485 / 100μlE20-74498-AF546$485 / 100μlE20-74498-AF594$485 / 100μlE20-74498-AF610$485 / 100μlE20-74498-AF635$485 / 100μlE20-74498-AF647$485 / 100μlE20-74498-AF680$485 / 100μlE20-74498-AF700$485 / 100μlE20-74498-AF750$485 / 100μlE20-74498-AF790$485 / 100μlE20-74498-APC$485 / 100μlE20-74498-PE$485 / 100μlE20-74498-Cy3$485 / 100μlE20-74498-Cy5$485 / 100μlE20-74498-Cy5.5$485 / 100μlE20-74498-Cy7$485 / 100μlE20-74498-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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