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Cell Signal Transduction Research Antibodies
Synuclein-α Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight14460 DaObserved Band:14 KD
Protein NameAlpha-synuclein
Human Gene Id6622
Human Swiss Prot NoP37840
Mouse Gene Id20617
Mouse Swiss Prot NoO55042
Rat Gene Id29219
Rat Swiss Prot NoP37377
SpecificitySynuclein-α Polyclonal Antibody detects endogenous levels of Synuclein-α protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameSNCA; NACP; PARK1; Alpha-synuclein; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP
Functionalternative products:Additional isoforms seem to exist,disease:Brain iron accumulation type 1 (NBIA1, also called Hallervorden-Spatz syndrome), a rare neuroaxonal dystrophy, is histologically characterized by axonal spheroids, iron deposition, Lewy body (LB)-like intraneuronal inclusions, glial inclusions and neurofibrillary tangles. SNCA is found in LB-like inclusions, glial inclusions and spheroids.,disease:Defects in SNCA are a cause of autosomal dominant Parkinson disease 1 (PARK1) [MIM:168601, 168600]. Parkinson disease (PD) is a complex, multifactorial disorder that typically manifests after the age of 50 years, although early-onset cases (before 50 years) are known. PD generally arises as a sporadic condition but is occasionally inherited as a simple mendelian trait. Although sporadic and familial PD are very similar, inherited forms of the disease usually begin at earlier ages an
Subcellular LocationCytoplasm . Membrane . Nucleus . Cell junction, synapse . Secreted . Cell projection, axon . Membrane-bound in dopaminergic neurons (PubMed:15282274). Expressed and colocalized with SEPTIN4 in dopaminergic axon terminals, especially at the varicosities (By similarity). .
ExpressionHighly expressed in presynaptic terminals in the central nervous system. Expressed principally in brain.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human Synuclein. AA range:15-64
Gene NameSNCA
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Backgroundsynuclein alpha(SNCA) Homo sapiens Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016],
Conjugated Antibody
This product is also available conjugated. Format: E20-74494-Conjugate. Price: $485 / Size: 100μl.
E20-74494-FITC$485 / 100μlE20-74494-Biotin$485 / 100μlE20-74494-HRP$485 / 100μlE20-74494-AP$485 / 100μlE20-74494-AF350$485 / 100μlE20-74494-AF405M$485 / 100μlE20-74494-AF488$485 / 100μlE20-74494-AF514$485 / 100μlE20-74494-AF532$485 / 100μlE20-74494-AF555$485 / 100μlE20-74494-AF568$485 / 100μlE20-74494-AF405S$485 / 100μlE20-74494-AF405L$485 / 100μlE20-74494-AF546$485 / 100μlE20-74494-AF594$485 / 100μlE20-74494-AF610$485 / 100μlE20-74494-AF635$485 / 100μlE20-74494-AF647$485 / 100μlE20-74494-AF680$485 / 100μlE20-74494-AF700$485 / 100μlE20-74494-AF750$485 / 100μlE20-74494-AF790$485 / 100μlE20-74494-APC$485 / 100μlE20-74494-PE$485 / 100μlE20-74494-Cy3$485 / 100μlE20-74494-Cy5$485 / 100μlE20-74494-Cy5.5$485 / 100μlE20-74494-Cy7$485 / 100μlE20-74494-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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