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Cell Signal Transduction Research Antibodies
Syntaxin 1 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight33023 DaObserved Band:35 KD
Protein NameSyntaxin-1A
Human Gene Id6804
Human Swiss Prot NoQ16623
Mouse Gene Id20907
Mouse Swiss Prot NoO35526
Rat Gene Id116470
Rat Swiss Prot NoP32851
SpecificitySyntaxin 1 Polyclonal Antibody detects endogenous levels of Syntaxin 1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameSTX1A; STX1; Syntaxin-1A; Neuron-specific antigen HPC-1
Functiondisease:Haploinsufficiency of STX1A may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS), a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23.,function:Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis.,similarity:Belongs to the syntaxin family.,similarity:Contains 1 t-SNARE coiled-coil homology domain.,subunit:Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A. This complex binds to CPLX1. Binds SYTL4 and STXBP6. Found in a ternary complex with STX1A and SNAP25. Interacts with OTOF (By similarity). Found in a complex with VAMP8 and SNAP23. Interacts with VAPA and SYBU.,tissue specificity:Isoform 1 is highly expressed in embryonic spinal chord and ganglia
Subcellular LocationCytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass type IV membrane protein . Cell junction, synapse, synaptosome . Cell membrane . Colocalizes with KCNB1 at the cell membrane. .; [Isoform 2]: Secreted .
Expression[Isoform 1]: Highly expressed in embryonic spinal cord and ganglia and in adult cerebellum and cerebral cortex. ; [Isoform 2]: Expressed in heart, liver, fat, skeletal muscle, kidney and brain.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human Syntaxin 1A. AA range:1-50
Gene NameSTX1A
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Backgroundsyntaxin 1A(STX1A) Homo sapiens This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009],
Conjugated Antibody
This product is also available conjugated. Format: E20-74493-Conjugate. Price: $485 / Size: 100μl.
E20-74493-FITC$485 / 100μlE20-74493-Biotin$485 / 100μlE20-74493-HRP$485 / 100μlE20-74493-AP$485 / 100μlE20-74493-AF350$485 / 100μlE20-74493-AF405M$485 / 100μlE20-74493-AF488$485 / 100μlE20-74493-AF514$485 / 100μlE20-74493-AF532$485 / 100μlE20-74493-AF555$485 / 100μlE20-74493-AF568$485 / 100μlE20-74493-AF405S$485 / 100μlE20-74493-AF405L$485 / 100μlE20-74493-AF546$485 / 100μlE20-74493-AF594$485 / 100μlE20-74493-AF610$485 / 100μlE20-74493-AF635$485 / 100μlE20-74493-AF647$485 / 100μlE20-74493-AF680$485 / 100μlE20-74493-AF700$485 / 100μlE20-74493-AF750$485 / 100μlE20-74493-AF790$485 / 100μlE20-74493-APC$485 / 100μlE20-74493-PE$485 / 100μlE20-74493-Cy3$485 / 100μlE20-74493-Cy5$485 / 100μlE20-74493-Cy5.5$485 / 100μlE20-74493-Cy7$485 / 100μlE20-74493-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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