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Cell Signal Transduction Research Antibodies
Synaptotagmin Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight47573/46872 DaObserved Band:60 KD
Protein NameSynaptotagmin-1/2
Human Gene Id6857/127833
Human Swiss Prot NoP21579/Q8N9I0
Mouse Gene Id20979/20980
Rat Gene Id25716/24805
Rat Swiss Prot NoP21707/P29101
SpecificitySynaptotagmin Polyclonal Antibody detects endogenous levels of Synaptotagmin protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameSYT1; SVP65; SYT; Synaptotagmin-1; Synaptotagmin I; SytI; p65; SYT2; Synaptotagmin-2; Synaptotagmin II; SytII
Functioncofactor:Binds 3 calcium ions per subunit. The ions are bound to the C2 domains.,domain:The first C2 domain mediates Ca(2+)-dependent phospholipid binding.,domain:The second C2 domain mediates interaction with SV2A and STN2.,function:May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.,similarity:Belongs to the synaptotagmin family.,similarity:Contains 2 C2 domains.,subcellular location:Synaptic vesicles and chromaffin granules.,subunit:H
Subcellular LocationCytoplasmic vesicle, secretory vesicle membrane ; Single-pass membrane protein . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass membrane protein . Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane ; Single-pass membrane protein . Cytoplasm .
ExpressionExpressed in melanocytes (PubMed:23999003).
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human Synaptotagmin. AA range:176-225
Gene NameSYT1/SYT2
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Backgroundsynaptotagmin 1(SYT1) Homo sapiens The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 [PubMed 11242035]).[supplied by OMIM, Jul 2010],
Conjugated Antibody
This product is also available conjugated. Format: E20-74485-Conjugate. Price: $485 / Size: 100μl.
E20-74485-FITC$485 / 100μlE20-74485-Biotin$485 / 100μlE20-74485-HRP$485 / 100μlE20-74485-AP$485 / 100μlE20-74485-AF350$485 / 100μlE20-74485-AF405M$485 / 100μlE20-74485-AF488$485 / 100μlE20-74485-AF514$485 / 100μlE20-74485-AF532$485 / 100μlE20-74485-AF555$485 / 100μlE20-74485-AF568$485 / 100μlE20-74485-AF405S$485 / 100μlE20-74485-AF405L$485 / 100μlE20-74485-AF546$485 / 100μlE20-74485-AF594$485 / 100μlE20-74485-AF610$485 / 100μlE20-74485-AF635$485 / 100μlE20-74485-AF647$485 / 100μlE20-74485-AF680$485 / 100μlE20-74485-AF700$485 / 100μlE20-74485-AF750$485 / 100μlE20-74485-AF790$485 / 100μlE20-74485-APC$485 / 100μlE20-74485-PE$485 / 100μlE20-74485-Cy3$485 / 100μlE20-74485-Cy5$485 / 100μlE20-74485-Cy5.5$485 / 100μlE20-74485-Cy7$485 / 100μlE20-74485-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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