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Cell Signal Transduction Research Antibodies
Synapsin I Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight73988 DaObserved Band:74 KD
Protein NameSynapsin-1
Human Gene Id6853
Human Swiss Prot NoP17600
Mouse Gene Id20964
Mouse Swiss Prot NoO88935
Rat Gene Id24949
Rat Swiss Prot NoP09951
SpecificitySynapsin I Polyclonal Antibody detects endogenous levels of Synapsin I protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameSYN1; Synapsin-1; Brain protein 4.1; Synapsin I
Functiondisease:Defects in SYN1 are a cause of epilepsy X-linked with variable learning disabilities and behavior disorders [MIM:300491]. XELBD is characterized by variable combinations of epilepsy, learning difficulties, macrocephaly, and aggressive behavior.,function:Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.,PTM:Substrate of at least four different protein kinases. It is probable that phosphorylation plays a role in the regulation of synapsin-1 in the nerve terminal. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the synapsin family.,subunit:Homodimer. Interacts with CAPON. Forms a ternary complex with NOS1. Isoform Ib interacts with
Subcellular LocationCell junction, synapse. Golgi apparatus .
ExpressionBrain,Brain cortex,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human Synapsin. AA range:3-52
Gene NameSYN1
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Backgroundsynapsin I(SYN1) Homo sapiens This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-74483-Conjugate. Price: $485 / Size: 100μl.
E20-74483-FITC$485 / 100μlE20-74483-Biotin$485 / 100μlE20-74483-HRP$485 / 100μlE20-74483-AP$485 / 100μlE20-74483-AF350$485 / 100μlE20-74483-AF405M$485 / 100μlE20-74483-AF488$485 / 100μlE20-74483-AF514$485 / 100μlE20-74483-AF532$485 / 100μlE20-74483-AF555$485 / 100μlE20-74483-AF568$485 / 100μlE20-74483-AF405S$485 / 100μlE20-74483-AF405L$485 / 100μlE20-74483-AF546$485 / 100μlE20-74483-AF594$485 / 100μlE20-74483-AF610$485 / 100μlE20-74483-AF635$485 / 100μlE20-74483-AF647$485 / 100μlE20-74483-AF680$485 / 100μlE20-74483-AF700$485 / 100μlE20-74483-AF750$485 / 100μlE20-74483-AF790$485 / 100μlE20-74483-APC$485 / 100μlE20-74483-PE$485 / 100μlE20-74483-Cy3$485 / 100μlE20-74483-Cy5$485 / 100μlE20-74483-Cy5.5$485 / 100μlE20-74483-Cy7$485 / 100μlE20-74483-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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