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Cell Signal Transduction Research Antibodies
Syk Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight72066 DaObserved Band:72 KD
Protein NameTyrosine-protein kinase SYK
Human Gene Id6850
Human Swiss Prot NoP43405
Mouse Gene Id20963
Mouse Swiss Prot NoP48025
Rat Gene Id25155
Rat Swiss Prot NoQ64725
SpecificitySyk Polyclonal Antibody detects endogenous levels of Syk protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameSYK; Tyrosine-protein kinase SYK; Spleen tyrosine kinase; p72-Syk
Functioncatalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Positive effector of BCR-stimulated responses. Couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C-gamma-dependent pathway, when phosphorylated on Tyr-348 and Tyr-352. Thus the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion.,PTM:Autophosphorylated.,PTM:Phosphorylation on Tyr-323 creates a binding site for c-Cbl, an adapter protein that serves as a negative regulator of BCR-stimulated calcium ion signaling.,PTM:Phosphorylation on Tyr-348 and Tyr-352 enhances the phosphorylation and activation of phospholipase C-gamma and the early phas
Subcellular LocationCell membrane . Cytoplasm, cytosol .
ExpressionWidely expressed in hematopoietic cells (at protein level) (PubMed:8163536). Expressed in neutrophils (at protein level) (PubMed:15123770). Within the B-cell compartment, expressed from pro- and pre-B cells to plasma cells (PubMed:8163536).
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human SYK. AA range:491-540
Gene NameSYK
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Backgroundspleen associated tyrosine kinase(SYK) Homo sapiens This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010],
Conjugated Antibody
This product is also available conjugated. Format: E20-74477-Conjugate. Price: $485 / Size: 100μl.
E20-74477-FITC$485 / 100μlE20-74477-Biotin$485 / 100μlE20-74477-HRP$485 / 100μlE20-74477-AP$485 / 100μlE20-74477-AF350$485 / 100μlE20-74477-AF405M$485 / 100μlE20-74477-AF488$485 / 100μlE20-74477-AF514$485 / 100μlE20-74477-AF532$485 / 100μlE20-74477-AF555$485 / 100μlE20-74477-AF568$485 / 100μlE20-74477-AF405S$485 / 100μlE20-74477-AF405L$485 / 100μlE20-74477-AF546$485 / 100μlE20-74477-AF594$485 / 100μlE20-74477-AF610$485 / 100μlE20-74477-AF635$485 / 100μlE20-74477-AF647$485 / 100μlE20-74477-AF680$485 / 100μlE20-74477-AF700$485 / 100μlE20-74477-AF750$485 / 100μlE20-74477-AF790$485 / 100μlE20-74477-APC$485 / 100μlE20-74477-PE$485 / 100μlE20-74477-Cy3$485 / 100μlE20-74477-Cy5$485 / 100μlE20-74477-Cy5.5$485 / 100μlE20-74477-Cy7$485 / 100μlE20-74477-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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