MMP-3 Polyclonal Antibody

Name: MMP-3 Polyclonal Antibody
Brand: EnoGene Biotech Co. Ltd
SKU: E20-74465
Price: 225 USD
Availability: InStock

E20-74465Cite ID: EN0054598Datasheet COA MSDS

SourcePolyclonal, Rabbit

$225/ 100ul

Quantity

Total: $225

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

OverviewImages & Data (2)Documents

Product Information

Molecular Weight53977 DaObserved Band:53 KD

Protein NameStromelysin-1

Human Gene Id4314

Human Swiss Prot NoP08254

Mouse Gene Id17392

Mouse Swiss Prot NoP28862

Rat Swiss Prot NoP03957

SpecificityMMP-3 Polyclonal Antibody detects endogenous levels of MMP-3 protein.

FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration1 mg/ml

Storage Stability-20°C/1 year

Other NameMMP3; STMY1; Stromelysin-1; SL-1; Matrix metalloproteinase-3; MMP-3; Transin-1

Functioncatalytic activity:Preferential cleavage where P1', P2' and P3' are hydrophobic residues.,cofactor:Binds 2 zinc ions per subunit.,cofactor:Binds 4 calcium ions per subunit.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,function:Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 4 hemopexin-like domains.,

Subcellular LocationSecreted, extracellular space, extracellular matrix .

ExpressionFibroblast,Lung,Synovium,

PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

ImmunogenThe antiserum was produced against synthesized peptide derived from human MMP-3. AA range:421-470

Gene NameMMP3

DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

Backgroundmatrix metallopeptidase 3(MMP3) Homo sapiens Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008],

📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Lot-specific COA (generated from product data)🧪MSDS
Material safety data sheet (generated)

Conjugated Antibody

This product is also available conjugated. Format: E20-74465-Conjugate. Price: $485 / Size: 100μl.

E20-74465-FITC$485 / 100μlE20-74465-Biotin$485 / 100μlE20-74465-HRP$485 / 100μlE20-74465-AP$485 / 100μlE20-74465-AF350$485 / 100μlE20-74465-AF405M$485 / 100μlE20-74465-AF488$485 / 100μlE20-74465-AF514$485 / 100μlE20-74465-AF532$485 / 100μlE20-74465-AF555$485 / 100μlE20-74465-AF568$485 / 100μlE20-74465-AF405S$485 / 100μlE20-74465-AF405L$485 / 100μlE20-74465-AF546$485 / 100μlE20-74465-AF594$485 / 100μlE20-74465-AF610$485 / 100μlE20-74465-AF635$485 / 100μlE20-74465-AF647$485 / 100μlE20-74465-AF680$485 / 100μlE20-74465-AF700$485 / 100μlE20-74465-AF750$485 / 100μlE20-74465-AF790$485 / 100μlE20-74465-APC$485 / 100μlE20-74465-PE$485 / 100μlE20-74465-Cy3$485 / 100μlE20-74465-Cy5$485 / 100μlE20-74465-Cy5.5$485 / 100μlE20-74465-Cy7$485 / 100μlE20-74465-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.