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Cell Signal Transduction Research Antibodies
Strad Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight48369 DaObserved Band:46 KD
Protein NameSTE20-related kinase adapter protein alpha
Human Gene Id92335
Human Swiss Prot NoQ7RTN6
Mouse Gene Id72149
Mouse Swiss Prot NoQ3UUJ4
SpecificityStrad Polyclonal Antibody detects endogenous levels of Strad protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameSTRADA; LYK5; STRAD; STE20-related kinase adapter protein alpha; STRAD alpha; STE20-related adapter protein; Serologically defined breast cancer antigen NY-BR-96
Functiondisease:Deletions involving STRADA are the cause of polyhydramnios, megalencephaly, and symptomatic epilepsy syndrome (PMSE) [MIM:611087]. Affected children have large heads, infantile-onset intractable multifocal seizures and severe psychomotor retardation. Neuropathological studies reveal megalencephaly, ventriculomegaly, cytomegaly and extensive vacuolization and astrocytosis of white matter.,domain:The protein kinase domain is predicted to be catalytically inactive.,function:Pseudokinase which, in complex with CAB39, binds to and activates STK11. Relocates STK11 from the nucleus to the cytoplasm. Plays an essential role in STK11-mediated G1 cell cycle arrest.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 protein kinase domain.,
Subcellular LocationNucleus . Cytoplasm .
ExpressionLymph node,Mammary tumor,Synovial membrane tissue,Teratocarcinoma,U
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human STRAD. AA range:11-60
Gene NameSTRADA
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
BackgroundSTE20-related kinase adaptor alpha(STRADA) Homo sapiens The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq, Sep 2009],
Conjugated Antibody
This product is also available conjugated. Format: E20-74464-Conjugate. Price: $485 / Size: 100μl.
E20-74464-FITC$485 / 100μlE20-74464-Biotin$485 / 100μlE20-74464-HRP$485 / 100μlE20-74464-AP$485 / 100μlE20-74464-AF350$485 / 100μlE20-74464-AF405M$485 / 100μlE20-74464-AF488$485 / 100μlE20-74464-AF514$485 / 100μlE20-74464-AF532$485 / 100μlE20-74464-AF555$485 / 100μlE20-74464-AF568$485 / 100μlE20-74464-AF405S$485 / 100μlE20-74464-AF405L$485 / 100μlE20-74464-AF546$485 / 100μlE20-74464-AF594$485 / 100μlE20-74464-AF610$485 / 100μlE20-74464-AF635$485 / 100μlE20-74464-AF647$485 / 100μlE20-74464-AF680$485 / 100μlE20-74464-AF700$485 / 100μlE20-74464-AF750$485 / 100μlE20-74464-AF790$485 / 100μlE20-74464-APC$485 / 100μlE20-74464-PE$485 / 100μlE20-74464-Cy3$485 / 100μlE20-74464-Cy5$485 / 100μlE20-74464-Cy5.5$485 / 100μlE20-74464-Cy7$485 / 100μlE20-74464-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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