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Cell Signal Transduction Research Antibodies
Stat6 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight94135 DaObserved Band:94 KD
Protein NameSignal transducer and activator of transcription 6
Human Gene Id6778
Human Swiss Prot NoP42226
Mouse Gene Id20852
Mouse Swiss Prot NoP52633
SpecificityStat6 Polyclonal Antibody detects endogenous levels of Stat6 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameSTAT6; Signal transducer and activator of transcription 6; IL-4 Stat
Functionfunction:Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling.,PTM:Tyrosine phosphorylated following stimulation by IL-4 and IL-3.,similarity:Belongs to the transcription factor STAT family.,similarity:Contains 1 SH2 domain.,subcellular location:Translocated into the nucleus in response to phosphorylation.,subunit:Forms a homodimer or a heterodimer with a related family member (By similarity). Interacts with NCOA1 via its C-terminal LXXLL motif.,
Subcellular LocationCytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.
ExpressionUterus,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human STAT6. AA range:612-661
Gene NameSTAT6
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Backgroundsignal transducer and activator of transcription 6(STAT6) Homo sapiens The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010],
Conjugated Antibody
This product is also available conjugated. Format: E20-74455-Conjugate. Price: $485 / Size: 100μl.
E20-74455-FITC$485 / 100μlE20-74455-Biotin$485 / 100μlE20-74455-HRP$485 / 100μlE20-74455-AP$485 / 100μlE20-74455-AF350$485 / 100μlE20-74455-AF405M$485 / 100μlE20-74455-AF488$485 / 100μlE20-74455-AF514$485 / 100μlE20-74455-AF532$485 / 100μlE20-74455-AF555$485 / 100μlE20-74455-AF568$485 / 100μlE20-74455-AF405S$485 / 100μlE20-74455-AF405L$485 / 100μlE20-74455-AF546$485 / 100μlE20-74455-AF594$485 / 100μlE20-74455-AF610$485 / 100μlE20-74455-AF635$485 / 100μlE20-74455-AF647$485 / 100μlE20-74455-AF680$485 / 100μlE20-74455-AF700$485 / 100μlE20-74455-AF750$485 / 100μlE20-74455-AF790$485 / 100μlE20-74455-APC$485 / 100μlE20-74455-PE$485 / 100μlE20-74455-Cy3$485 / 100μlE20-74455-Cy5$485 / 100μlE20-74455-Cy5.5$485 / 100μlE20-74455-Cy7$485 / 100μlE20-74455-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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