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Cell Signal Transduction Research Antibodies
Stat5 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight89866 DaObserved Band:90 KD
Protein NameSignal transducer and activator of transcription 5A/B
Human Gene Id6777
Human Swiss Prot NoP42229/P51692
Mouse Gene Id20850/20851
Rat Gene Id24918/25126
Rat Swiss Prot NoQ62771/P52632
SpecificityStat5 Polyclonal Antibody detects endogenous levels of Stat5 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameSTAT5A; STAT5; Signal transducer and activator of transcription 5A; STAT5B; Signal transducer and activator of transcription 5B
Functionfunction:Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription.,online information:STAT5 entry,PTM:Tyrosine phosphorylated in response to IL-2, IL-3, IL-7, IL-15, GM-CSF, growth hormone, prolactin, erythropoietin and thrombopoietin. Tyrosine phosphorylation is required for DNA-binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity.,similarity:Belongs to the transcription factor STAT family.,similarity:Contains 1 SH2 domain.,subcellular location:Translocated into the nucleus in response to phosphorylation.,subunit:Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with NCOA1 and SOCS7.,
Subcellular LocationCytoplasm . Nucleus . Translocated into the nucleus in response to phosphorylation.
ExpressionBrain,Cervix,Epithelium,Lung,Placenta,Synovial memb
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human STAT5B. AA range:697-746
Gene NameSTAT5A/STAT5B
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Backgroundsignal transducer and activator of transcription 5A(STAT5A) Homo sapiens The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been
Conjugated Antibody
This product is also available conjugated. Format: E20-74450-Conjugate. Price: $485 / Size: 100μl.
E20-74450-FITC$485 / 100μlE20-74450-Biotin$485 / 100μlE20-74450-HRP$485 / 100μlE20-74450-AP$485 / 100μlE20-74450-AF350$485 / 100μlE20-74450-AF405M$485 / 100μlE20-74450-AF488$485 / 100μlE20-74450-AF514$485 / 100μlE20-74450-AF532$485 / 100μlE20-74450-AF555$485 / 100μlE20-74450-AF568$485 / 100μlE20-74450-AF405S$485 / 100μlE20-74450-AF405L$485 / 100μlE20-74450-AF546$485 / 100μlE20-74450-AF594$485 / 100μlE20-74450-AF610$485 / 100μlE20-74450-AF635$485 / 100μlE20-74450-AF647$485 / 100μlE20-74450-AF680$485 / 100μlE20-74450-AF700$485 / 100μlE20-74450-AF750$485 / 100μlE20-74450-AF790$485 / 100μlE20-74450-APC$485 / 100μlE20-74450-PE$485 / 100μlE20-74450-Cy3$485 / 100μlE20-74450-Cy5$485 / 100μlE20-74450-Cy5.5$485 / 100μlE20-74450-Cy7$485 / 100μlE20-74450-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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