World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
Stat4 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight85941 DaObserved Band:85 KD
Protein NameSignal transducer and activator of transcription 4
Human Gene Id6775
Human Swiss Prot NoQ14765
Mouse Gene Id20849
Mouse Swiss Prot NoP42228
SpecificityStat4 Polyclonal Antibody detects endogenous levels of Stat4 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameSTAT4; Signal transducer and activator of transcription 4
Functiondisease:Genetic variations in STAT4 are associated with susceptibility to rheumatoid arthritis (RA) [MIM:180300]. Rheumatoid arthritis is a complex, multifactorial disorder. It is one of the most common autoimmune diseases and it is characterized by inflammation of synovial tissue and joint destruction.,disease:Genetic variations in STAT4 are associated with susceptibility to systemic lupus erythematosus type 11 (SLEB11) [MIM:612253]. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.,function:Carries out a dual function: signal transduction and activation of transcription. I
Subcellular LocationCytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.
ExpressionBrain,Kidney,Pancreas,Spleen,Testis,Uterus,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human STAT4. AA range:660-709
Gene NameSTAT4
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunoprecipitation: 2-5 ug/mg lysate. ELISA: 1/5000. Not yet tested in other applications.
Backgroundsignal transducer and activator of transcription 4(STAT4) Homo sapiens The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011],
Conjugated Antibody
This product is also available conjugated. Format: E20-74447-Conjugate. Price: $485 / Size: 100μl.
E20-74447-FITC$485 / 100μlE20-74447-Biotin$485 / 100μlE20-74447-HRP$485 / 100μlE20-74447-AP$485 / 100μlE20-74447-AF350$485 / 100μlE20-74447-AF405M$485 / 100μlE20-74447-AF488$485 / 100μlE20-74447-AF514$485 / 100μlE20-74447-AF532$485 / 100μlE20-74447-AF555$485 / 100μlE20-74447-AF568$485 / 100μlE20-74447-AF405S$485 / 100μlE20-74447-AF405L$485 / 100μlE20-74447-AF546$485 / 100μlE20-74447-AF594$485 / 100μlE20-74447-AF610$485 / 100μlE20-74447-AF635$485 / 100μlE20-74447-AF647$485 / 100μlE20-74447-AF680$485 / 100μlE20-74447-AF700$485 / 100μlE20-74447-AF750$485 / 100μlE20-74447-AF790$485 / 100μlE20-74447-APC$485 / 100μlE20-74447-PE$485 / 100μlE20-74447-Cy3$485 / 100μlE20-74447-Cy5$485 / 100μlE20-74447-Cy5.5$485 / 100μlE20-74447-Cy7$485 / 100μlE20-74447-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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