World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
Stat3 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight88068 DaObserved Band:88 KD
Protein NameSignal transducer and activator of transcription 3
Human Gene Id6774
Human Swiss Prot NoP40763
Mouse Gene Id20848
Mouse Swiss Prot NoP42227
Rat Gene Id25125
Rat Swiss Prot NoP52631
SpecificityStat3 Polyclonal Antibody detects endogenous levels of Stat3 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameSTAT3; APRF; Signal transducer and activator of transcription 3; Acute-phase response factor
Functiondisease:Defects in STAT3 are the cause of hyperimmunoglobulin E recurrent infection syndrome autosomal dominant (AD-HIES) [MIM:147060]; also known as hyper-IgE syndrome or Job syndrome. AD-HIES is a rare disorder of immunity and connective tissue characterized by immunodeficiency, chronic eczema, recurrent Staphylococcal infections, increased serum IgE, eosinophilia, distinctive coarse facial appearance, abnormal dentition, hyperextensibility of the joints, and bone fractures.,function:Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA.,miscellaneous:Involved in the gp130-mediated signaling pathway.,online information:STAT3 entry,online information:STAT3 mutation db,PTM:Tyrosine phosphorylated in response to IL-6, IL-11, CNTF, LIF, CSF-1, EGF, PDGF, IFN-alpha an
Subcellular LocationCytoplasm . Nucleus . Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3. Identified in a complex with LYN and PAG1.
ExpressionHeart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in naive CD4(+) T cells as well as T-helper Th17, Th1 and Th2 cells (PubMed:31899195).
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human STAT3. AA range:694-743
Gene NameSTAT3
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Backgroundsignal transducer and activator of transcription 3(STAT3) Homo sapiens The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper
Conjugated Antibody
This product is also available conjugated. Format: E20-74445-Conjugate. Price: $485 / Size: 100μl.
E20-74445-FITC$485 / 100μlE20-74445-Biotin$485 / 100μlE20-74445-HRP$485 / 100μlE20-74445-AP$485 / 100μlE20-74445-AF350$485 / 100μlE20-74445-AF405M$485 / 100μlE20-74445-AF488$485 / 100μlE20-74445-AF514$485 / 100μlE20-74445-AF532$485 / 100μlE20-74445-AF555$485 / 100μlE20-74445-AF568$485 / 100μlE20-74445-AF405S$485 / 100μlE20-74445-AF405L$485 / 100μlE20-74445-AF546$485 / 100μlE20-74445-AF594$485 / 100μlE20-74445-AF610$485 / 100μlE20-74445-AF635$485 / 100μlE20-74445-AF647$485 / 100μlE20-74445-AF680$485 / 100μlE20-74445-AF700$485 / 100μlE20-74445-AF750$485 / 100μlE20-74445-AF790$485 / 100μlE20-74445-APC$485 / 100μlE20-74445-PE$485 / 100μlE20-74445-Cy3$485 / 100μlE20-74445-Cy5$485 / 100μlE20-74445-Cy5.5$485 / 100μlE20-74445-Cy7$485 / 100μlE20-74445-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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