World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
Stat2 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight97916 DaObserved Band:113 KD
Protein NameSignal transducer and activator of transcription 2
Human Gene Id6773
Human Swiss Prot NoP52630
Mouse Swiss Prot NoQ9WVL2
SpecificityStat2 Polyclonal Antibody detects endogenous levels of Stat2 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameSTAT2; Signal transducer and activator of transcription 2; p113
Functionfunction:Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.,PTM:Tyrosine phosphorylated in response to IFN-alpha.,similarity:Belongs to the transcription factor STAT family.,similarity:Contains 1 SH2 domain.,subcellular location:Translocated into the nucleus upon activation by IFN-alpha/beta.,subunit:Interacts with ISGF3G/IRF-9 in the cytoplasm. Heterodimer with STAT1 upon I
Subcellular LocationCytoplasm . Nucleus . Translocated into the nucleus upon activation by IFN-alpha/beta. .
ExpressionHuman small intestine,Lung,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human STAT2. AA range:656-705
Gene NameSTAT2
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Backgroundsignal transducer and activator of transcription 2(STAT2) Homo sapiens The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010],
Conjugated Antibody
This product is also available conjugated. Format: E20-74442-Conjugate. Price: $485 / Size: 100μl.
E20-74442-FITC$485 / 100μlE20-74442-Biotin$485 / 100μlE20-74442-HRP$485 / 100μlE20-74442-AP$485 / 100μlE20-74442-AF350$485 / 100μlE20-74442-AF405M$485 / 100μlE20-74442-AF488$485 / 100μlE20-74442-AF514$485 / 100μlE20-74442-AF532$485 / 100μlE20-74442-AF555$485 / 100μlE20-74442-AF568$485 / 100μlE20-74442-AF405S$485 / 100μlE20-74442-AF405L$485 / 100μlE20-74442-AF546$485 / 100μlE20-74442-AF594$485 / 100μlE20-74442-AF610$485 / 100μlE20-74442-AF635$485 / 100μlE20-74442-AF647$485 / 100μlE20-74442-AF680$485 / 100μlE20-74442-AF700$485 / 100μlE20-74442-AF750$485 / 100μlE20-74442-AF790$485 / 100μlE20-74442-APC$485 / 100μlE20-74442-PE$485 / 100μlE20-74442-Cy3$485 / 100μlE20-74442-Cy5$485 / 100μlE20-74442-Cy5.5$485 / 100μlE20-74442-Cy7$485 / 100μlE20-74442-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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