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Cell Signal Transduction Research Antibodies
STAM2 Polyclonal Antibody
Human;Mouse
WB;IHC-p;IF/ICC;ELISA
Polyclonal, Rabbit,IgG
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human STAM2. AA range:161-210
Gene NameSTAM2
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
Product Information
Protein NameSignal transducing adapter molecule 2
Human Gene Id10254
Human Swiss Prot NoO75886
Mouse Gene Id56324
Mouse Swiss Prot NoO88811
SpecificitySTAM2 Polyclonal Antibody detects endogenous levels of STAM2 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameSTAM2; HBP; Signal transducing adapter molecule 2; STAM-2; Hrs-binding protein
Observed Band(KD)58
Functiondomain:Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain.,domain:The SH3 domain mediates the interaction with USP8.,domain:The VHS and UIM domains mediate the interaction with ubiquitinated proteins.,function:Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and c-myc induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential
Subcellular LocationCytoplasm . Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side .
ExpressionUbiquitously expressed.
BackgroundThe protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-74435-Conjugate. Price: $485 / Size: 100μl.
E20-74435-FITC$485 / 100μlE20-74435-Biotin$485 / 100μlE20-74435-HRP$485 / 100μlE20-74435-AP$485 / 100μlE20-74435-AF350$485 / 100μlE20-74435-AF405M$485 / 100μlE20-74435-AF488$485 / 100μlE20-74435-AF514$485 / 100μlE20-74435-AF532$485 / 100μlE20-74435-AF555$485 / 100μlE20-74435-AF568$485 / 100μlE20-74435-AF405S$485 / 100μlE20-74435-AF405L$485 / 100μlE20-74435-AF546$485 / 100μlE20-74435-AF594$485 / 100μlE20-74435-AF610$485 / 100μlE20-74435-AF635$485 / 100μlE20-74435-AF647$485 / 100μlE20-74435-AF680$485 / 100μlE20-74435-AF700$485 / 100μlE20-74435-AF750$485 / 100μlE20-74435-AF790$485 / 100μlE20-74435-APC$485 / 100μlE20-74435-PE$485 / 100μlE20-74435-Cy3$485 / 100μlE20-74435-Cy5$485 / 100μlE20-74435-Cy5.5$485 / 100μlE20-74435-Cy7$485 / 100μlE20-74435-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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