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Cell Signal Transduction Research Antibodies
ST5 Polyclonal Antibody
Human;Mouse
WB;ELISA
Polyclonal, Rabbit,IgG
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human ST5. AA range:411-460
Gene NameST5
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Product Information
Protein NameSuppression of tumorigenicity 5 protein
Human Gene Id6764
Human Swiss Prot NoP78524
Mouse Gene Id76954
Mouse Swiss Prot NoQ924W7
SpecificityST5 Polyclonal Antibody detects endogenous levels of ST5 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameST5; DENND2B; HTS1; Suppression of tumorigenicity 5 protein; DENN domain-containing protein 2B; HeLa tumor suppression 1
Observed Band(KD)126
Functionfunction:May be involved in cytoskeletal organization and tumorgenicity. Isoform 1 seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Isoform 3 may block ERK2 activation stimulated by ABL1. Isoform 3 may alter cell morphology and cell growth.,similarity:Contains 1 dDENN domain.,similarity:Contains 1 DENN domain.,similarity:Contains 1 uDENN domain.,subunit:Isoform 1 interacts with the SH3 domain of ABL1.,tissue specificity:Widely expressed with the exception of peripheral blood lymphocytes. Isoform 1 is expressed in several epithelial and fibroblast (including tumorigenic) but absent in lymphoid cell lines (at protein level). Isoform 3 is expressed in primary cell or weakly tumorigenic but not in tumorigenic cell lines (at protein level).,
Subcellular Location[Isoform 1]: Cytoplasm, cell cortex . Cell membrane . Recycling endosome . Colocalizes with RAB13 and ITSN1 at cytoplasmic vesicles that are most likely recycling endosomes. Colocalizes with the cortical actin cytoskeleton. .
ExpressionWidely expressed with the exception of peripheral blood lymphocytes. Isoform 1 is expressed in several epithelial and fibroblast (including tumorigenic) but absent in lymphoid cell lines (at protein level). Isoform 3 is expressed in primary cell or weakly tumorigenic but not in tumorigenic cell lines (at protein level).
BackgroundThis gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-74432-Conjugate. Price: $485 / Size: 100μl.
E20-74432-FITC$485 / 100μlE20-74432-Biotin$485 / 100μlE20-74432-HRP$485 / 100μlE20-74432-AP$485 / 100μlE20-74432-AF350$485 / 100μlE20-74432-AF405M$485 / 100μlE20-74432-AF488$485 / 100μlE20-74432-AF514$485 / 100μlE20-74432-AF532$485 / 100μlE20-74432-AF555$485 / 100μlE20-74432-AF568$485 / 100μlE20-74432-AF405S$485 / 100μlE20-74432-AF405L$485 / 100μlE20-74432-AF546$485 / 100μlE20-74432-AF594$485 / 100μlE20-74432-AF610$485 / 100μlE20-74432-AF635$485 / 100μlE20-74432-AF647$485 / 100μlE20-74432-AF680$485 / 100μlE20-74432-AF700$485 / 100μlE20-74432-AF750$485 / 100μlE20-74432-AF790$485 / 100μlE20-74432-APC$485 / 100μlE20-74432-PE$485 / 100μlE20-74432-Cy3$485 / 100μlE20-74432-Cy5$485 / 100μlE20-74432-Cy5.5$485 / 100μlE20-74432-Cy7$485 / 100μlE20-74432-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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