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Cell Signal Transduction Research Antibodies
SSH3 Polyclonal Antibody
Human;Mouse;Rat
WB;IHC-p;IF(paraffin section);ELISA
Polyclonal, Rabbit,IgG
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human SSH3. AA range:357-406
Gene NameSSH3
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Product Information
Protein NameProtein phosphatase Slingshot homolog 3
Human Gene Id54961
Human Swiss Prot NoQ8TE77
Mouse Gene Id245857
Mouse Swiss Prot NoQ8K330
Rat Gene Id365396
Rat Swiss Prot NoQ5XIS1
SpecificitySSH3 Polyclonal Antibody detects endogenous levels of SSH3 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameSSH3; SSH3L; Protein phosphatase Slingshot homolog 3; SSH-like protein 3; SSH-3L; hSSH-3L
Observed Band(KD)74
Functioncatalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,function:Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly.,miscellaneous:Tyrosine phosphatase activity has not been demonstrated for this protein to date.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein-tyrosine phosphatase family.,similarity:Contains 1 tyrosine-protein phosphatase domain.,subunit:Does not bind to, or colocalize with, filamentous actin.,
Subcellular LocationCytoplasm, cytoskeleton . Nucleus .
ExpressionCerebellum,Epithelium,Ovarian carcinoma,Uterus,
BackgroundThe ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002 [PubMed 11832213]).[supplied by OMIM, Mar 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-74428-Conjugate. Price: $485 / Size: 100μl.
E20-74428-FITC$485 / 100μlE20-74428-Biotin$485 / 100μlE20-74428-HRP$485 / 100μlE20-74428-AP$485 / 100μlE20-74428-AF350$485 / 100μlE20-74428-AF405M$485 / 100μlE20-74428-AF488$485 / 100μlE20-74428-AF514$485 / 100μlE20-74428-AF532$485 / 100μlE20-74428-AF555$485 / 100μlE20-74428-AF568$485 / 100μlE20-74428-AF405S$485 / 100μlE20-74428-AF405L$485 / 100μlE20-74428-AF546$485 / 100μlE20-74428-AF594$485 / 100μlE20-74428-AF610$485 / 100μlE20-74428-AF635$485 / 100μlE20-74428-AF647$485 / 100μlE20-74428-AF680$485 / 100μlE20-74428-AF700$485 / 100μlE20-74428-AF750$485 / 100μlE20-74428-AF790$485 / 100μlE20-74428-APC$485 / 100μlE20-74428-PE$485 / 100μlE20-74428-Cy3$485 / 100μlE20-74428-Cy5$485 / 100μlE20-74428-Cy5.5$485 / 100μlE20-74428-Cy7$485 / 100μlE20-74428-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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