SSB Polyclonal Antibody

Name: SSB Polyclonal Antibody
Brand: EnoGene Biotech Co. Ltd
SKU: E20-74425
Price: 225 USD
Availability: InStock

E20-74425Cite ID: EN0054558Datasheet COA MSDS

ReactivityHuman;Rat;Mouse;

ApplicationsWB;IHC-p;IF(paraffin section);ELISA

SourcePolyclonal, Rabbit,IgG

$225/ 100ul

Quantity

Total: $225

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

OverviewImages & Data (2)Documents

PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

ImmunogenThe antiserum was produced against synthesized peptide derived from human SSB. AA range:341-390

Gene NameSSB

DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

Product Information

Protein NameLupus La protein

Human Gene Id6741

Human Swiss Prot NoP05455

Mouse Swiss Prot NoP32067

SpecificitySSB Polyclonal Antibody detects endogenous levels of SSB protein.

FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration1 mg/ml

Storage Stability-20°C/1 year

Other NameSSB; Lupus La protein; La autoantigen; La ribonucleoprotein; Sjoegren syndrome type B antigen; SS-B

Observed Band(KD)47

Functiondisease:Sera from patients with systemic lupus erythematosus (SLE) often contain antibodies that react with the normal cellular La protein as if this antigen was foreign.,function:La protein plays a role in the transcription of RNA polymerase III. It is most probably a transcription termination factor. Binds to the 3' termini of virtually all nascent polymerase III transcripts. It is associated with precursor forms of RNA polymerase III transcripts including tRNA and 4.5S, 5S, 7S, and 7-2 RNAs.,PTM:Phosphorylated. The phosphorylation sites are at the C-terminal part of the protein.,PTM:The N-terminus is blocked.,similarity:Contains 1 HTH La-type RNA-binding domain.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subunit:Interacts with DDX15. May interact with RUFY1.,

Subcellular LocationNucleus .

ExpressionEpithelium,Liver,Placenta,Skeletal muscle,

BackgroundSjogren syndrome antigen B(SSB) Homo sapiens The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. [provided by RefSeq, Jun 2014],

📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Lot-specific COA (generated from product data)🧪MSDS
Material safety data sheet (generated)

Conjugated Antibody

This product is also available conjugated. Format: E20-74425-Conjugate. Price: $485 / Size: 100μl.

E20-74425-FITC$485 / 100μlE20-74425-Biotin$485 / 100μlE20-74425-HRP$485 / 100μlE20-74425-AP$485 / 100μlE20-74425-AF350$485 / 100μlE20-74425-AF405M$485 / 100μlE20-74425-AF488$485 / 100μlE20-74425-AF514$485 / 100μlE20-74425-AF532$485 / 100μlE20-74425-AF555$485 / 100μlE20-74425-AF568$485 / 100μlE20-74425-AF405S$485 / 100μlE20-74425-AF405L$485 / 100μlE20-74425-AF546$485 / 100μlE20-74425-AF594$485 / 100μlE20-74425-AF610$485 / 100μlE20-74425-AF635$485 / 100μlE20-74425-AF647$485 / 100μlE20-74425-AF680$485 / 100μlE20-74425-AF700$485 / 100μlE20-74425-AF750$485 / 100μlE20-74425-AF790$485 / 100μlE20-74425-APC$485 / 100μlE20-74425-PE$485 / 100μlE20-74425-Cy3$485 / 100μlE20-74425-Cy5$485 / 100μlE20-74425-Cy5.5$485 / 100μlE20-74425-Cy7$485 / 100μlE20-74425-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.