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SR-6 Polyclonal Antibody
Datasheet
Catalog Number:
E20-74408Amount:
100ulMolecular Weight:
46954DaPurification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human 5-HT-6. AA range:221-270Source:
Polyclonal, Rabbit
- Western Blot analysis of A549 cells using SR-6 Polyclonal Antibody
Gene Name:
HTR6Dilution:
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.Background:
5-hydroxytryptamine receptor 6(HTR6) Homo sapiens This gene encodes a protein that belongs to the seven-transmembrane G protein-coupled receptor family of proteins. The encoded protein couples with the Gs alpha subunit and stimulates adenylate cyclase to activate the cyclic AMP-dependent signaling pathway. This receptor is thought to regulate cholinergic neuronal transmission in the brain. Several antidepressants and antipsychotic drugs have a high affinity for this receptor. [provided by RefSeq, Aug 2013],Protein Name:
5-hydroxytryptamine receptor 6Human Gene Id:
3362Human Swiss Prot No:
P50406Mouse Gene Id:
15565Mouse Swiss Prot No:
Q9R1C8Rat Gene Id:
64354Rat Swiss Prot No:
P31388Specificity:
SR-6 Polyclonal Antibody detects endogenous levels of SR-6 protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
HTR6; 5-hydroxytryptamine receptor 6; 5-HT-6; 5-HT6; Serotonin receptor 6Observed Band(KD):
47Function:
function:This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed in several human brain regions, most prominently in the caudate nucleus.,Subcellular Location:
Cell membrane; Multi-pass membrane protein.Expression:
Expressed in several human brain regions, most prominently in the caudate nucleus.
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