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SR-4 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-74404

  • Amount:

    100ul

  • Molecular Weight:

    43761Da

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human HTR4. AA range:141-190

  • Source:

    Polyclonal, Rabbit

  • Western blot analysis of the lysates from HepG2 cells using HTR4 antibody.

  • Gene Name:

    HTR4

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

  • Background:

    5-hydroxytryptamine receptor 4(HTR4) Homo sapiens This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described. [provided by RefSeq, May 2010],

  • Protein Name:

    5-hydroxytryptamine receptor 4

  • Human Gene Id:

    3360

  • Human Swiss Prot No:

    Q13639

  • Mouse Swiss Prot No:

    P97288

  • Rat Gene Id:

    25324

  • Rat Swiss Prot No:

    Q62758

  • Specificity:

    SR-4 Polyclonal Antibody detects endogenous levels of SR-4 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    HTR4; 5-hydroxytryptamine receptor 4; 5-HT-4; 5-HT4; Serotonin receptor 4

  • Observed Band(KD):

    43

  • Function:

    alternative products:Additional isoforms seem to exist,function:This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.,similarity:Belongs to the G-protein coupled receptor 1 family.,subcellular location:Interaction with SNX27 mediates recruitment to early endosomes, while interaction with SLC9A3R1 and EZR might target the protein to specialized subcellular regions, such as microvilli.,subunit:Isoform 5-HT4(A) interacts with MAGI2, MPP3, SLC9A3R1 and SNX27 isoforms 1 and 2. Isoform 5-HT4(E) interacts with INADL, NOS1 and SEC23A. Isoform 5-HT4(A) forms a complex including SLC9A3R1 and EZR.,tissue specificity:Isoform 5-HT4(A) is expressed in ileum, brain, and atrium, but not in the ventricle.

  • Subcellular Location:

    Cell membrane; Multi-pass membrane protein. Endosome. Interaction with SNX27 mediates recruitment to early endosomes, while interaction with SLC9A3R1 and EZR might target the protein to specialized subcellular regions, such as microvilli. .

  • Expression:

    Isoform 5-HT4(A) is expressed in ileum, brain, and atrium, but not in the ventricle.

  • Immunofluorescence analysis of MCF7 cells, using HTR4 Antibody. The picture on the right is blocked with the synthesized peptide.

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Catalog Number

  • Amount:100ul
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SR-4 Polyclonal Antibody | EnoGene Biotech Co. Ltd