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Cell Signal Transduction Research Antibodies
SR-3A Polyclonal Antibody
Human;Rat;Mouse;
WB;IHC-p;IF/ICC;ELISA
Polyclonal, Rabbit,IgG
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human 5-HT-3A. AA range:161-210
Gene NameHTR3A
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Product Information
Protein Name5-hydroxytryptamine receptor 3A
Human Gene Id3359
Human Swiss Prot NoP46098
Mouse Swiss Prot NoP23979
SpecificitySR-3A Polyclonal Antibody detects endogenous levels of SR-3A protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameHTR3A; 5HT3R; HTR3; 5-hydroxytryptamine receptor 3A; 5-HT3-A; 5-HT3A; 5-hydroxytryptamine receptor 3; 5-HT-3; 5-HT3R; Serotonin receptor 3A; Serotonin-gated ion channel receptor
Observed Band(KD)55
Functionfunction:This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel.,miscellaneous:The HA-stretch region of HTR3A seems to be responsible for the low conductance of HTR3A homomers compared to that of HTR3A/HTR3B heteromers.,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Forms pentahomomeric complex as well as pentaheteromeric complex with HTR3B or HTR3C or HTR3D or HTR3E; homomeric complex are functional but exhibit low conductance, decreased agonist and antagonist affinity with modified voltage dependence. Interacts with RIC3.,tissue specificity:Expressed in cer
Subcellular LocationCell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
ExpressionExpressed in cerebral cortex, amygdala, hippocampus, and testis. Detected in monocytes of the spleen and tonsil, in small and large intestine, uterus, prostate, ovary and placenta.
BackgroundThe product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-74401-Conjugate. Price: $485 / Size: 100μl.
E20-74401-FITC$485 / 100μlE20-74401-Biotin$485 / 100μlE20-74401-HRP$485 / 100μlE20-74401-AP$485 / 100μlE20-74401-AF350$485 / 100μlE20-74401-AF405M$485 / 100μlE20-74401-AF488$485 / 100μlE20-74401-AF514$485 / 100μlE20-74401-AF532$485 / 100μlE20-74401-AF555$485 / 100μlE20-74401-AF568$485 / 100μlE20-74401-AF405S$485 / 100μlE20-74401-AF405L$485 / 100μlE20-74401-AF546$485 / 100μlE20-74401-AF594$485 / 100μlE20-74401-AF610$485 / 100μlE20-74401-AF635$485 / 100μlE20-74401-AF647$485 / 100μlE20-74401-AF680$485 / 100μlE20-74401-AF700$485 / 100μlE20-74401-AF750$485 / 100μlE20-74401-AF790$485 / 100μlE20-74401-APC$485 / 100μlE20-74401-PE$485 / 100μlE20-74401-Cy3$485 / 100μlE20-74401-Cy5$485 / 100μlE20-74401-Cy5.5$485 / 100μlE20-74401-Cy7$485 / 100μlE20-74401-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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