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SR-1B Polyclonal Antibody
Datasheet
Catalog Number:
E20-74392Amount:
100ulMolecular Weight:
43568DaApplications:
WB;IHC-pReactivity:
Human;Mouse;RatPurification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human HTR1B. AA range:261-310Source:
Polyclonal, Rabbit,IgGGene Name:
HTR1BDilution:
WB 1:500-2000;IHC-p 1:50-300
- Western blot analysis of the lysates from COLO205 cells using HTR1B antibody.
Background:
The protein encoded by this intronless gene is a G-protein coupled receptor for serotonin (5-hydroxytryptamine). Ligand binding activates second messengers that inhibit the activity of adenylate cyclase and manage the release of serotonin, dopamine, and acetylcholine in the brain. The encoded protein may be involved in several neuropsychiatric disorders and therefore is often a target of antidepressant and other psychotherapeutic drugs. [provided by RefSeq, Nov 2015],Protein Name:
5-hydroxytryptamine receptor 1BHuman Gene Id:
3351Human Swiss Prot No:
P28222Mouse Gene Id:
15551Mouse Swiss Prot No:
P28334Rat Gene Id:
25075Rat Swiss Prot No:
P28564Specificity:
SR-1B Polyclonal Antibody detects endogenous levels of SR-1B protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
HTR1B; HTR1DB; 5-hydroxytryptamine receptor 1B; 5-HT-1B; 5-HT1B; S12; Serotonin 1D beta receptor; 5-HT-1D-beta; Serotonin receptor 1BObserved Band(KD):
48Function:
function:This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.,PTM:Palmitoylated.,PTM:Phosphorylated. Desensitization of the receptor may be mediated by its phosphorylation.,similarity:Belongs to the G-protein coupled receptor 1 family.,Subcellular Location:
Cell membrane ; Multi-pass membrane protein .Expression:
Detected in cerebral artery smooth muscle cells (at protein level). Detected in brain cortex, striatum, amygdala, medulla, hippocampus, caudate nucleus and putamen.
- Immunohistochemical analysis of paraffin-embedded human tonsil. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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