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SLC4A8/10 Polyclonal Antibody
Datasheet
Catalog Number:
E20-74316Amount:
100ulSwiss-Prot No.:
Q2Y0W8/Q6U841Molecular Weight:
125.9kd Observed Band 140kdApplications:
WB,IHC-p,IF(paraffin section),ELISAReactivity:
Human,Mouse,RatPurification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human SLC4A8/10. AA range:411-460Specificity/Sensitivity:
SLC4A8/10 Polyclonal Antibody detects endogenous levels of SLC4A8/10 protein.Storage/Stability:
-20°C/1 yearSource:
Rabbit
- Western Blot analysis of COLO cells using SLC4A8/10 Polyclonal Antibody diluted at 1:500
Gene Name:
SLC4A8/SLC4A10Dilution:
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.Background:
solute carrier family 4 member 8(SLC4A8) Homo sapiens The protein encoded by this gene is a membrane protein that functions to transport sodium and bicarbonate ions across the cell membrane. The encoded protein is important for pH regulation in neurons. The activity of this protein can be inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012],Gene ID:
57282/9498Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azideFunction:
Mediates electroneutral sodium- and carbonate-dependent choride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity.,miscellaneous:Activity is inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of severalanionic channels and transporters).,similarity:Belongs to the anion exchanger (TC 2.A.31) family.,tissue specificity:Expressed in the pyramidal cells of the hippocampus (atprotein level). Highly expressed in all major regions of the brain, spinal column and in testis, and moderate levels in trache
- Western blot analysis of lysates from COLO cells, using SLC4A8/10 Antibody. The lane on the right is blocked with the synthesized peptide.
- Western blot analysis of the lysates from HUVECcells using SLC4A8/10 antibody.
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