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Septin 5 Polyclonal Antibody
Datasheet
Catalog Number:
E20-74249Amount:
100ulPrice:
225$Purification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
Synthesized peptide derived from Septin 5 . at AA range: 180-260Source:
Polyclonal, RabbitGene Name:
SEPT5Dilution:
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
- Western blot analysis of lysates from DU145 cells, primary antibody was diluted at 1:1000, 4°over night
Background:
septin 5(SEPT5) Homo sapiens This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced. [provided by RefSeq, Dec 2010],Protein Name:
Septin-5Human Gene Id:
5413Human Swiss Prot No:
Q99719Mouse Gene Id:
18951Mouse Swiss Prot No:
Q9Z2Q6Rat Gene Id:
116728Rat Swiss Prot No:
Q9JJM9Specificity:
Septin 5 Polyclonal Antibody detects endogenous levels of Septin 5 protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
SEPT5; PNUTL1; Septin-5; Cell division control-related protein 1; CDCrel-1; Peanut-like protein 1MolecularWeight(Da):
42777Observed Band(KD):
42Function:
function:Involved in cytokinesis .,similarity:Belongs to the septin family.,subunit:May assemble into a multicomponent structure.,Subcellular Location:
cytoskeleton,plasma membrane,cell cortex,synaptic vesicle,terminal bouton,Expression:
Brain,Cajal-Retzius cell,Fetal brain cortex,Heart,Lung,Platelet,
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