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Sar1B Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-74214

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human SAR1B. AA range:111-160

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    SAR1B

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

  • Immunohistochemistry analysis of paraffin-embedded human placenta tissue, using SAR1B Antibody. The picture on the right is blocked with the synthesized peptide.

  • Background:

    secretion associated Ras related GTPase 1B(SAR1B) Homo sapiens The protein encoded by this gene is a small GTPase that acts as a homodimer. The encoded protein is activated by the guanine nucleotide exchange factor PREB and is involved in protein transport from the endoplasmic reticulum to the Golgi. This protein is part of the COPII coat complex. Defects in this gene are a cause of chylomicron retention disease (CMRD), also known as Anderson disease (ANDD). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010],

  • Protein Name:

    GTP-binding protein SAR1b

  • Human Gene Id:

    51128

  • Human Swiss Prot No:

    Q9Y6B6

  • Mouse Gene Id:

    66397

  • Mouse Swiss Prot No:

    Q9CQC9

  • Rat Gene Id:

    287276

  • Rat Swiss Prot No:

    Q5HZY2

  • Specificity:

    Sar1B Polyclonal Antibody detects endogenous levels of Sar1B protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    SAR1B; SARA2; SARB; GTP-binding protein SAR1b; GTP-binding protein B; GTBPB

  • MolecularWeight(Da):

    22410

  • Observed Band(KD):

    22

  • Function:

    disease:Defects in SAR1B are the cause of chylomicron retention disease (CMRD) [MIM:246700]; also known as Anderson disease (ANDD). CMRD is an autosomal recessive disorder of severe fat malabsorption associated with failure to thrive in infancy. The condition is characterized by deficiency of fat-soluble vitamins, low blood cholesterol levels, and a selective absence of chylomicrons from blood. Affected individuals accumulate chylomicron-like particles in membrane-bound compartments of enterocytes, which contain large cytosolic lipid droplets.,function:Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex.,similarity:Belongs to the small GTPase superfamily.,similarity:Belongs to the small GTPase superfamily. SAR1 family

  • Subcellular Location:

    intracellular,endoplasmic reticulum,endoplasmic reticulum membrane,Golgi apparatus,cytosol,ER to Golgi transport vesicle membrane,Golgi cisterna membrane,

  • Expression:

    Pituitary tumor,Placenta,Prostate,Small intestine,Testis,

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Catalog Number

  • Amount:100ul
  • Price:225$

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Sar1B Polyclonal Antibody | EnoGene Biotech Co. Ltd