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Rho GDIα Polyclonal Antibody
Datasheet
Catalog Number:
E20-74081Amount:
100ulApplications:
IHC-p;IF(paraffin section);ELISAReactivity:
Human;Mouse;RatPurification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human ARHGDIA. AA range:140-189Source:
Polyclonal, RabbitGene Name:
ARHGDIADilution:
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
- Immunohistochemistry analysis of paraffin-embedded human cervix carcinoma tissue, using ARHGDIA Antibody. The picture on the right is blocked with the synthesized peptide.
Background:
Rho GDP dissociation inhibitor alpha(ARHGDIA) Homo sapiens This gene encodes a protein that plays a key role in the regulation of signaling through Rho GTPases. The encoded protein inhibits the disassociation of Rho family members from GDP (guanine diphosphate), thereby maintaining these factors in an inactive state. Activity of this protein is important in a variety of cellular processes, and expression of this gene may be altered in tumors. Mutations in this gene have been found in individuals with nephrotic syndrome, type 8. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],Protein Name:
Rho GDP-dissociation inhibitor 1Human Gene Id:
396Human Swiss Prot No:
P52565Mouse Gene Id:
192662Mouse Swiss Prot No:
Q99PT1Rat Gene Id:
360678Rat Swiss Prot No:
Q5XI73Specificity:
Rho GDIα Polyclonal Antibody detects endogenous levels of Rho GDIα protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
ARHGDIA; GDIA1; Rho GDP-dissociation inhibitor 1; Rho GDI 1; Rho-GDI alphaMolecularWeight(Da):
23207Function:
function:Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.,similarity:Belongs to the Rho GDI family.,subunit:Monomer.,Subcellular Location:
immunological synapse,extracellular space,nucleus,cytoplasm,cytosol,cytoskeleton,extracellular exosome,Expression:
Brain,Cajal-Retzius cell,Colon,Epithelium,Fetal brain cortex,Lung,M
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