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Rho G Polyclonal Antibody
Datasheet
Catalog Number:
E20-74080Amount:
100ulApplications:
WB;IHC-p;IF(paraffin section);ELISAReactivity:
Human;Mouse;RatPurification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human RHOG. AA range:97-146Source:
Polyclonal, RabbitGene Name:
RHOGDilution:
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
- Western blot analysis of lysates from Jurkat cells, using RHOG Antibody. The lane on the right is blocked with the synthesized peptide.
Background:
ras homolog family member G(RHOG) Homo sapiens This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to the plasma membrane where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium formation and cell migration. Two related pseudogene have been identified on chromosomes 20 and X. [provided by RefSeq, Aug 2011],Protein Name:
Rho-related GTP-binding protein RhoGHuman Gene Id:
391Human Swiss Prot No:
P84095Mouse Gene Id:
56212Mouse Swiss Prot No:
P84096Specificity:
Rho G Polyclonal Antibody detects endogenous levels of Rho G protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
RHOG; ARHG; Rho-related GTP-binding protein RhoGMolecularWeight(Da):
21309Observed Band(KD):
23Function:
function:Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry.,similarity:Belongs to the small GTPase superfamily. Rho family.,subunit:Interacts with SGEF.,Subcellular Location:
intracellular,endoplasmic reticulum membrane,cytosol,plasma membrane,focal adhesion,extracellular exosome,Expression:
Brain,PCR rescued clones,
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