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RAGE Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-73993

  • Amount:

    100ul

  • Reactivity:

    Human,Rat,Mouse

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human RAGE. AA range:133-182

  • Source:

    Polyclonal, Rabbit

  • Western Blot analysis of 3T3 cells using RAGE Polyclonal Antibody diluted at 1:1000

  • Gene Name:

    AGER

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications

  • Protein Name:

    Advanced glycosylation end product-specific receptor

  • Human Gene Id:

    177

  • Human Swiss Prot No:

    Q15109

  • Specificity:

    RAGE Polyclonal Antibody detects endogenous levels of RAGE protein

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    AGER; RAGE; Advanced glycosylation end product-specific receptor; Receptor for advanced glycosylation end productsMolecularWeight:42803/36193Da

  • Observed Band(KD):

    37

  • Background:

    advanced glycosylation end-product specific receptor(AGER) Homo sapiens The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011]

  • Function:

    function:Mediates interactions of advanced glycosylation end products (AGE). These arenonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Receptor for amyloid beta peptide.,similarity:Contains 1 Ig-like V-type(immunoglobulin-like) domain.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:Endothelial cells

  • Subcellular Location:

    extracellular region,plasma membrane,integral component of plasma membrane,integral component of membrane

  • Immunohistochemistry analysis of RAGE antibody in paraffin-embedded human lung carcinoma tissue.

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Catalog Number

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