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Rad21 Polyclonal Antibody
Datasheet
Catalog Number:
E20-73960Amount:
100ulSwiss-Prot No.:
O60216/ Q61550Molecular Weight:
71690，Observed Band : 72kdPrice:
225$Applications:
WB,IHC-p,IF/ICC,ELISAReactivity:
Human,MousePurification:
The antibody was affinity-purified from rabbit antiserum by affinitychromatography using epitope-specific immunogenImmunogen:
The antiserum was produced against synthesized peptide derived from human
RAD21. AA range:521-570Specificity/Sensitivity:
Rad21 Polyclonal Antibody detects endogenous levels of Rad21 protein.Storage/Stability:
-20°C/1 yearSource:
RabbitGene Name:
RAD21Dilution:
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300.Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other
- Western blot analysis of lysates from Jurkat cells, using RAD21
Antibody. The lane on the right is blocked with the synthesized
peptide. Background:
RAD21 cohesin complex component(RAD21) Homo sapiens The protein
encoded by this gene is highly similar to the gene product of
Schizosaccharomyces pombe rad21, a gene involved in the repair of DNA doublestrand breaks, as well as in chromatid cohesion during mitosis. This protein is a
nuclear phospho-protein, which becomes hyperphosphorylated in cell cycle M
phase. The highly regulated association of this protein with mitotic chromatin
specifically at the centromere region suggests its role in sister chromatid cohesion
in mitotic cells. [provided by RefSeq, Jul 2008]Gene ID:
5885/19357Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azideFunction:
domain:The C-terminal part associates with the head of SMC1A, while the Nterminal part binds to the head of SMC3.,function:Cleavable component of thecohesin complex, involved in chromosome cohesion during cell cycle, in DNArepair, and in apoptosis. The cohesin complex is required for the cohesion ofsister chromatids after DNA replication. The cohesin complex apparently forms alarge proteinaceous ring within which sister chromatids can be trapped. Atmetaphase-anaphase transition, this protein is cleaved by separase/ESPL1 anddissociates from chromatin, allowing sister chromatids to segregate. The cohesincomplex may also play a role in spindle pole assembly during mitosis. Also playsa role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7during early steps of apoptosis: the C-terminal 64 kDa cleavage product may actas a nuclear signal to initiate cytoplasmic ev
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