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PMS2/PMS2CL Polyclonal Antibody
Datasheet
Catalog Number:
E20-73805Amount:
100ulPrice:
225$Purification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human PMS2CL. AA range:125-174Source:
Polyclonal, RabbitGene Name:
PMS2/PMS2CLDilution:
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
- Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using PMS2/PMS2CL Antibody. The picture on the right is blocked with the synthesized peptide.
Background:
caution:According to PubMed:15077197, it is a pseudogene. However, a peptide specific to this protein was identified by mass spectrometry (PubMed:17525332). Given that the product described by PubMed:15077197 is located downstream and on another frame of the transcript, it may explain why PubMed:15256438 could not detect this protein on a Western blot.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Wrong choice of transcript.,similarity:Belongs to the DNA mismatch repair mutL/hexB family.,Protein Name:
Mismatch repair endonuclease PMS2/Protein PMS2CLHuman Gene Id:
5395Human Swiss Prot No:
Q68D20/P54278Specificity:
PMS2/PMS2CL Polyclonal Antibody detects endogenous levels of PMS2/PMS2CL protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
PMS2CL; Protein PMS2CL; PMS2-C terminal-like protein; PMS2; PMSL2; Mismatch repair endonuclease PMS2; DNA mismatch repair protein PMS2; PMS1 protein homolog 2MolecularWeight(Da):
20909Function:
caution:According to PubMed:15077197, it is a pseudogene. However, a peptide specific to this protein was identified by mass spectrometry (PubMed:17525332). Given that the product described by PubMed:15077197 is located downstream and on another frame of the transcript, it may explain why PubMed:15256438 could not detect this protein on a Western blot.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Wrong choice of transcript.,similarity:Belongs to the DNA mismatch repair mutL/hexB family.,Subcellular Location:
mismatch repair complex,Expression:
Fetal brain,Testis,
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