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PLC γ2 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-73794

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human PLCG2. AA range:1186-1235

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    PLCG2

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

  • Immunohistochemistry analysis of paraffin-embedded human brain tissue, using PLCG2 Antibody. The picture on the right is blocked with the synthesized peptide.

  • Background:

    phospholipase C gamma 2(PLCG2) Homo sapiens The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014],

  • Protein Name:

    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

  • Human Gene Id:

    5336

  • Human Swiss Prot No:

    P16885

  • Mouse Gene Id:

    234779

  • Mouse Swiss Prot No:

    Q8CIH5

  • Rat Gene Id:

    29337

  • Rat Swiss Prot No:

    P24135

  • Specificity:

    PLC γ2 Polyclonal Antibody detects endogenous levels of PLC γ2 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    PLCG2; 1-phosphatidylinositol 4; 5-bisphosphate phosphodiesterase gamma-2; Phosphoinositide phospholipase C-gamma-2; Phospholipase C-IV; PLC-IV; Phospholipase C-gamma-2; PLC-gamma-2

  • MolecularWeight(Da):

    147937

  • Observed Band(KD):

    147

  • Function:

    catalytic activity:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.,cofactor:Calcium.,function:The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.,PTM:Phosphorylated on tyrosine residues; upon ligand-induced activation of a variety of growth factor receptors and immune system receptors. Increases phospholipase activity.,similarity:Contains 1 C2 domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 PI-PLC X-box domain.,similarity:Contains 1 PI-PLC Y-box domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 2 SH2 domains.,

  • Subcellular Location:

    intracellular,cytosol,plasma membrane,extracellular exosome,

  • Expression:

    Lymph,Lymphoblast,Spleen,T-cell,

  • Western blot analysis of lysates from Raw264.7 cells, treated with PMA 125ng/ml 30', using PLCG2 Antibody. The lane on the right is blocked with the synthesized peptide.

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Catalog Number

  • Amount:100ul
  • Price:225$

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PLC γ2 Polyclonal Antibody | EnoGene Biotech Co. Ltd