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Pki α Polyclonal Antibody
Datasheet
Catalog Number:
E20-73775Amount:
100ulPrice:
225$Purification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human IPKA. AA range:10-59Source:
Polyclonal, RabbitGene Name:
PKIADilution:
Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
- Immunofluorescence analysis of HeLa cells, using IPKA Antibody. The picture on the right is blocked with the synthesized peptide.
Background:
protein kinase (cAMP-dependent, catalytic) inhibitor alpha(PKIA) Homo sapiens The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. This protein was demonstrated to interact with and inhibit the activities of both C alpha and C beta catalytic subunits of the PKA. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008],Protein Name:
cAMP-dependent protein kinase inhibitor alphaHuman Gene Id:
5569Human Swiss Prot No:
P61925Mouse Gene Id:
18767Mouse Swiss Prot No:
P63248Rat Gene Id:
114906Rat Swiss Prot No:
P63249Specificity:
Pki α Polyclonal Antibody detects endogenous levels of Pki α protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
PKIA; PRKACN1; cAMP-dependent protein kinase inhibitor alpha; PKI-alpha; cAMP-dependent protein kinase inhibitor; muscle/brain isoformMolecularWeight(Da):
7989Function:
function:Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.,miscellaneous:The inhibitory site contains regions very similar to the hinge regions (sites that directly interact with the enzyme active site) and "pseudosubstrate site" of the regulatory chains; but, unlike these chains, PKI does not contain cAMP-binding sites. The arginine residues within the inhibitory site are essential for inhibition and recognition of the enzyme active site.,similarity:Belongs to the PKI family.,Subcellular Location:
nucleus,cytoplasm,Expression:
Skeletal muscle,
- Immunohistochemistry analysis of paraffin-embedded human brain tissue, using IPKA Antibody. The picture on the right is blocked with the synthesized peptide.
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Catalog Number
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