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PKAβ cat Polyclonal Antibody
Datasheet
Catalog Number:
E20-73750Amount:
100ulPrice:
225$Purification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human KAPCB. AA range:291-340Source:
Polyclonal, RabbitGene Name:
PRKACBDilution:
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
- Western blot analysis of lysates from Jurkat and COLO205 cells, using KAPCB Antibody. The lane on the right is blocked with the synthesized peptide.
Background:
protein kinase cAMP-activated catalytic subunit beta(PRKACB) Homo sapiens The protein encoded by this gene is a member of the serine/threonine protein kinase family. The encoded protein is a catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase, which mediates signalling though cAMP. cAMP signaling is important to a number of processes, including cell proliferaton and differentiation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2014],Protein Name:
cAMP-dependent protein kinase catalytic subunit betaHuman Gene Id:
5567Human Swiss Prot No:
P22694Mouse Gene Id:
18749Mouse Swiss Prot No:
P68181Rat Gene Id:
293508Rat Swiss Prot No:
P68182Specificity:
PKAβ cat Polyclonal Antibody detects endogenous levels of PKAβ cat protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
PRKACB; cAMP-dependent protein kinase catalytic subunit beta; PKA C-betaMolecularWeight(Da):
40623Observed Band(KD):
53Function:
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by cAMP.,function:Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux.,PTM:Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,subcellularSubcellular Location:
nucleoplasm,centrosome,cytosol,plasma membrane,cAMP-dependent protein kinase complex,perinuclear region of cytoplasm,extracellular exosome,ciliary base,Expression:
Brain,Placenta,Retina,Salivary gland,Testis,Trachea
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Catalog Number
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