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PI 3-Kinase p110γ Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-73710

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human PIK3CG. AA range:881-930

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    PIK3CG

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

  • Western blot analysis of PIK3CG Antibody. The lane on the right is blocked with the PIK3CG peptide.

  • Background:

    phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma(PIK3CG) Homo sapiens Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I catalytic subunit of PI3K. Like other class I catalytic subunits (p110-alpha p110-beta, and p110-delta), the encoded protein binds a p85 regulatory subunit to form PI3K. This gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2015],

  • Protein Name:

    Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

  • Human Gene Id:

    5294

  • Human Swiss Prot No:

    P48736

  • Mouse Swiss Prot No:

    Q9JHG7

  • Specificity:

    PI 3-Kinase p110γ Polyclonal Antibody detects endogenous levels of PI 3-Kinase p110γ protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    PIK3CG; Phosphatidylinositol 4; 5-bisphosphate 3-kinase catalytic subunit gamma isoform; PI3-kinase subunit gamma; PI3K-gamma; PI3Kgamma; PtdIns-3-kinase subunit gamma; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit

  • MolecularWeight(Da):

    126454

  • Observed Band(KD):

    120

  • Function:

    catalytic activity:ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.,enzyme regulation:Activated by both the alpha and the beta-gamma G proteins.,function:3-phosphorylates the cellular phosphoinositide PtdIns-4,5-biphosphate (PtdIns(4,5)P2) to produce PtdIns-3, 4,5-triiphosphate (PtdIns(3,4,5)P3). Links G-protein coupled receptor activation to the secondary messenger PtdIns(3,4,5)P3 production.,pathway:Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.,similarity:Belongs to the PI3/PI4-kinase family.,similarity:Contains 1 PI3K/PI4K domain.,subunit:Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit.,tissue specificity:Pancreas, skeletal muscle, liver and heart.,

  • Subcellular Location:

    intracellular,cytoplasm,cytosol,plasma membrane,phosphatidylinositol 3-kinase complex,phosphatidylinositol 3-kinase complex, class IB,membrane,mast cell granule,

  • Expression:

    Pancreas,

  • Immunohistochemistryt analysis of paraffin-embedded human pancreas, using PIK3CG Antibody. The lane on the right is blocked with the PIK3CG peptide.

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Catalog Number

  • Amount:100ul
  • Price:225$

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PI 3-Kinase p110γ Polyclonal Antibody | EnoGene Biotech Co. Ltd