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PDGFR-β Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-73640

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human PDGFR beta. AA range:711-760

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    PDGFRB

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

  • Western blot analysis of lysates from Jurkat cells, treated with TNF-a 20ng/ml 5', using PDGFR beta Antibody. The lane on the right is blocked with the synthesized peptide.

  • Background:

    platelet derived growth factor receptor beta(PDGFRB) Homo sapiens This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Jul 2008],

  • Protein Name:

    Platelet-derived growth factor receptor beta

  • Human Gene Id:

    5159

  • Human Swiss Prot No:

    P09619

  • Mouse Gene Id:

    18596

  • Mouse Swiss Prot No:

    P05622

  • Rat Gene Id:

    24629

  • Rat Swiss Prot No:

    Q05030

  • Specificity:

    PDGFR-β Polyclonal Antibody detects endogenous levels of PDGFR-β protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    PDGFRB; PDGFR; PDGFR1; Platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-beta; Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; Platelet-deri

  • MolecularWeight(Da):

    123968

  • Observed Band(KD):

    130

  • Function:

    catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:A chromosomal aberration involving PDGFRB is a cause in many instances of chronic myeloproliferative disorder with eosinophilia (MPE) [MIM:131440]. Translocation t(5;12) with ETV6 on chromosome 12 creating an PDGFRB-ETV6 fusion protein.,disease:A chromosomal aberration involving PDGFRB is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;12)(q33;p13) with EVT6/TEL. It is characterized by abnormal clonal myeloid proliferation and by progression to acute myelogenous leukemia (AML).,disease:A chromosomal aberration involving PDGFRB may be a cause of acute myelogenous leukemia. Translocation t(5;14)(q33;q32) with TRIP11. The fusion protein may be involved in clonal evolution of leukemia and eosinophilia.,disease:A chromosomal aberration involving PDGFRB may be a cause

  • Subcellular Location:

    nucleus,cytoplasm,plasma membrane,focal adhesion,cell surface,membrane,integral component of membrane,cytoplasmic, membrane-bounded vesicle,apical plasma membrane,intrinsic component of plasma membrane,cytoplasmic v

  • Expression:

    Brain,Spleen,

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Catalog Number

  • Amount:100ul
  • Price:225$

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PDGFR-β Polyclonal Antibody | EnoGene Biotech Co. Ltd