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PCB Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-73616

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human PC. AA range:357-406

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    PC

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

  • Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using PC Antibody. The picture on the right is blocked with the synthesized peptide.

  • Background:

    pyruvate carboxylase(PC) Homo sapiens This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008],

  • Protein Name:

    Pyruvate carboxylase mitochondrial

  • Human Gene Id:

    5091

  • Human Swiss Prot No:

    P11498

  • Mouse Swiss Prot No:

    Q05920

  • Rat Gene Id:

    25104

  • Rat Swiss Prot No:

    P52873

  • Specificity:

    PCB Polyclonal Antibody detects endogenous levels of PCB protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    PC; Pyruvate carboxylase; mitochondrial; Pyruvic carboxylase; PCB

  • MolecularWeight(Da):

    129634

  • Observed Band(KD):

    120

  • Function:

    catalytic activity:ATP + pyruvate + HCO(3)(-) = ADP + phosphate + oxaloacetate.,cofactor:Binds 1 manganese ion per subunit.,cofactor:Biotin.,disease:Defects in PC are the cause of pyruvate carboxylase deficiency (PC deficiency) [MIM:266150]. PC deficiency leads to lactic acidosis, mental retardation and death. It occurs in three forms: mild or type A, severe neonatal or type B, and a very mild lacticacidemia.,function:Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate.,online information:Pyruvate carboxylase entry,pathway:Carbohydrate biosynthesis; gluconeogenesis.,similarity:Conta

  • Subcellular Location:

    cytoplasm,mitochondrion,mitochondrial matrix,cytosol,

  • Expression:

    Epithelium,Kidney,Liver,Lung,

  • Western blot analysis of lysates from Jurkat cells, using PC Antibody. The lane on the right is blocked with the synthesized peptide.

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Catalog Number

  • Amount:100ul
  • Price:225$

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PCB Polyclonal Antibody | EnoGene Biotech Co. Ltd