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PARP-4 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-73596

  • Amount:

    100ul

  • Molecular Weight:

    192589Da

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human PARP4. AA range:1151-1200

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    PARP4

  • Dilution:

    Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

  • Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using PARP4 Antibody. The picture on the right is blocked with the synthesized peptide.

  • Protein Name:

    Poly [ADP-ribose] polymerase 4

  • Human Gene Id:

    143

  • Human Swiss Prot No:

    Q9UKK3

  • Specificity:

    PARP-4 Polyclonal Antibody detects endogenous levels of PARP-4 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    PARP4; ADPRTL1; KIAA0177; PARPL; Poly [ADP-ribose] polymerase 4; PARP-4; 193 kDa vault protein; ADP-ribosyltransferase diphtheria toxin-like 4; ARTD4; PARP-related/IalphaI-related H5/proline-rich; PH5P; Vault poly(ADP-ribose) polymerase; VP

  • Background:

    poly(ADP-ribose) polymerase family member 4(PARP4) Homo sapiens This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus. [provided by RefSeq, Jul 2008],

  • Function:

    catalytic activity:NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.,similarity:Contains 1 BRCT domain.,similarity:Contains 1 PARP alpha-helical domain.,similarity:Contains 1 PARP catalytic domain.,similarity:Contains 1 VWFA domain.,subcellular location:Also found in the nucleus, associated with mitotic spindles.,subunit:Component of the vault ribonucleoprotein particle, at least composed of MVP, PARP4 and one or more vault RNAs (vRNAs). Binds to MVP. Associates with TEP1.,tissue specificity:Widely expressed; the highest levels are in the kidney; also detected in heart, placenta, lung, liver, skeletal muscle, spleen, leukocytes and pancreas.,

  • Subcellular Location:

    nucleus,cytoplasm,spindle microtubule,membrane,intracellular ribonucleoprotein complex,extracellular exosome,

  • Expression:

    Bone marrow,Thymus,

  • Western blot analysis of the lysates from HT-29 cells using FAF1 antibody.

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