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Cell Signal Transduction Research Antibodies
PARP-3 Polyclonal Antibody
Human;Rat;Mouse;Fields:>>Base excision repair;>>Apoptosis
IHC-p;IF(paraffin section);ELISA
Polyclonal, Rabbit,IgG
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight60089Da
Protein NamePoly [ADP-ribose] polymerase 3
Human Gene Id10039
Human Swiss Prot NoQ9Y6F1
SpecificityPARP-3 Polyclonal Antibody detects endogenous levels of PARP-3 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NamePARP3; ADPRT3; ADPRTL3; Poly [ADP-ribose] polymerase 3; PARP-3; hPARP-3; ADP-ribosyltransferase diphtheria toxin-like 3; ARTD3; IRT1; NAD(+) ADP-ribosyltransferase 3; ADPRT-3; Poly[ADP-ribose] synthase 3; pADPRT-3
Functioncatalytic activity:NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.,domain:According to PubMed:10329013 the N-terminal domain (54 amino acids) of isoform 2 is responsible for its centrosomal localization. The C-terminal region contains the catalytic domain.,function:Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 comple
Subcellular LocationNucleus . Chromosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Almost exclusively localized in the nucleus and appears in numerous small foci and a small number of larger foci whereas a centrosomal location has not been detected (PubMed:16924674). In response to DNA damage, localizes to sites of double-strand break (PubMed:21270334). Preferentially localized to the daughter centriole (PubMed:10329013). .
ExpressionWidely expressed; the highest levels are in the kidney, skeletal muscle, liver, heart and spleen; also detected in pancreas, lung, placenta, brain, leukocytes, colon, small intestine, ovary, testis, prostate and thymus.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human PARP3. AA range:10-59
Gene NamePARP3
DilutionImmunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
BackgroundThe protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-73595-Conjugate. Price: $485 / Size: 100μl.
E20-73595-FITC$485 / 100μlE20-73595-Biotin$485 / 100μlE20-73595-HRP$485 / 100μlE20-73595-AP$485 / 100μlE20-73595-AF350$485 / 100μlE20-73595-AF405M$485 / 100μlE20-73595-AF488$485 / 100μlE20-73595-AF514$485 / 100μlE20-73595-AF532$485 / 100μlE20-73595-AF555$485 / 100μlE20-73595-AF568$485 / 100μlE20-73595-AF405S$485 / 100μlE20-73595-AF405L$485 / 100μlE20-73595-AF546$485 / 100μlE20-73595-AF594$485 / 100μlE20-73595-AF610$485 / 100μlE20-73595-AF635$485 / 100μlE20-73595-AF647$485 / 100μlE20-73595-AF680$485 / 100μlE20-73595-AF700$485 / 100μlE20-73595-AF750$485 / 100μlE20-73595-AF790$485 / 100μlE20-73595-APC$485 / 100μlE20-73595-PE$485 / 100μlE20-73595-Cy3$485 / 100μlE20-73595-Cy5$485 / 100μlE20-73595-Cy5.5$485 / 100μlE20-73595-Cy7$485 / 100μlE20-73595-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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