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Cell Signal Transduction Research Antibodies
PARP-2 Polyclonal Antibody
Human;MouseFields:>>Base excision repair;>>Apoptosis
WB;ELISA
Polyclonal, Rabbit,IgG
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight66206Da
Protein NamePoly [ADP-ribose] polymerase 2
Human Gene Id10038
Human Swiss Prot NoQ9UGN5
Mouse Gene Id11546
Mouse Swiss Prot NoO88554
SpecificityPARP-2 Polyclonal Antibody detects endogenous levels of PARP-2 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NamePARP2; ADPRT2; ADPRTL2; Poly [ADP-ribose] polymerase 2; PARP-2; hPARP-2; ADP-ribosyltransferase diphtheria toxin-like 2; ARTD2; NAD(+) ADP-ribosyltransferase 2; ADPRT-2; Poly[ADP-ribose] synthase 2; pADPRT-2
Observed Band(KD)75
Functioncatalytic activity:NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.,function:Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.,PTM:Poly-ADP-ribosylated by PARP1.,similarity:Contains 1 PARP alpha-helical domain.,similarity:Contains 1 PARP catalytic domain.,subunit:Component of a base excision repair (BER) complex, containing at least XRCC1, PARP1, POLB and LIG3. Homo- and heterodimer with PARP1.,tissue specificity:Widely expressed, mainly in actively dividing tissues. The highest levels are in the brain, heart, pancreas, skeletal muscle and testis; also detected i
Subcellular LocationNucleus . Chromosome . Recruited to DNA damage sites. .
ExpressionWidely expressed, mainly in actively dividing tissues (PubMed:10364231). The highest levels are in the brain, heart, pancreas, skeletal muscle and testis; also detected in kidney, liver, lung, placenta, ovary and spleen; levels are low in leukocytes, colon, small intestine, prostate and thymus (PubMed:10364231).
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human PARP2. AA range:151-200
Gene NamePARP2
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
BackgroundThis gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-73594-Conjugate. Price: $485 / Size: 100μl.
E20-73594-FITC$485 / 100μlE20-73594-Biotin$485 / 100μlE20-73594-HRP$485 / 100μlE20-73594-AP$485 / 100μlE20-73594-AF350$485 / 100μlE20-73594-AF405M$485 / 100μlE20-73594-AF488$485 / 100μlE20-73594-AF514$485 / 100μlE20-73594-AF532$485 / 100μlE20-73594-AF555$485 / 100μlE20-73594-AF568$485 / 100μlE20-73594-AF405S$485 / 100μlE20-73594-AF405L$485 / 100μlE20-73594-AF546$485 / 100μlE20-73594-AF594$485 / 100μlE20-73594-AF610$485 / 100μlE20-73594-AF635$485 / 100μlE20-73594-AF647$485 / 100μlE20-73594-AF680$485 / 100μlE20-73594-AF700$485 / 100μlE20-73594-AF750$485 / 100μlE20-73594-AF790$485 / 100μlE20-73594-APC$485 / 100μlE20-73594-PE$485 / 100μlE20-73594-Cy3$485 / 100μlE20-73594-Cy5$485 / 100μlE20-73594-Cy5.5$485 / 100μlE20-73594-Cy7$485 / 100μlE20-73594-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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