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PARK2 Polyclonal Antibody
Datasheet
Catalog Number:
E20-73591Amount:
100ulPrice:
225$Purification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human Parkin. AA range:1-50Source:
Polyclonal, RabbitGene Name:
PARK2Dilution:
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
- Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Parkin Antibody. The picture on the right is blocked with the synthesized peptide.
Background:
parkin RBR E3 ubiquitin protein ligase(PARK2) Homo sapiens The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. [provided by RefSeq, Jul 2008],Protein Name:
E3 ubiquitin-protein ligase parkinHuman Gene Id:
5071Human Swiss Prot No:
O60260Mouse Gene Id:
50873Mouse Swiss Prot No:
Q9WVS6Rat Gene Id:
56816Rat Swiss Prot No:
Q9JK66Specificity:
PARK2 Polyclonal Antibody detects endogenous levels of PARK2 protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
PARK2; PRKN; E3 ubiquitin-protein ligase parkin; Parkinson juvenile disease protein 2; Parkinson disease protein 2MolecularWeight(Da):
51641Observed Band(KD):
52Function:
disease:Defects in PARK2 are a cause of Parkinson disease (PD) [MIM:168600]. PD is a complex, multifactorial disorder that typically manifests after the age of 50 years, although early-onset cases (before 50 years) are known. PD generally arises as a sporadic condition but is occasionally inherited as a simple mendelian trait. Although sporadic and familial PD are very similar, inherited forms of the disease usually begin at earlier ages and are associated with atypical clinical features. PD is characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology of PD involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain.,disease:DSubcellular Location:
ubiquitin ligase complex,nucleus,cytoplasm,mitochondrion,endoplasmic reticulum,Golgi apparatus,cytosol,aggresome,SCF ubiquitin ligase complex,neuron projection,protein complex,perinuclear region of cytoplasm,Expression:
Fetal brain,Skeletal muscle,Testis,
- Western blot analysis of lysates from Jurkat cells, using Parkin Antibody. The lane on the right is blocked with the synthesized peptide.
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Catalog Number
- Amount:100ul
- Price:225$
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