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PAR-3 Polyclonal Antibody
Datasheet
Catalog Number:
E20-73586Amount:
100ulMolecular Weight:
42508(Da)Price:
225$Purification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human F2RL2. AA range:38-87Source:
Polyclonal, RabbitGene Name:
F2RL2Dilution:
Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
- Immunofluorescence analysis of MCF7 cells, using F2RL2 Antibody. The picture on the right is blocked with the synthesized peptide.
Protein Name:
Proteinase-activated receptor 3Human Gene Id:
2151Human Swiss Prot No:
O00254Mouse Swiss Prot No:
O08675Specificity:
PAR-3 Polyclonal Antibody detects endogenous levels of PAR-3 protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
F2RL2; PAR3; Proteinase-activated receptor 3; PAR-3; Coagulation factor II receptor-like 2; Thrombin receptor-like 2Background:
coagulation factor II thrombin receptor like 2(F2RL2) Homo sapiens This gene encodes a member of the protease-activated receptor (PAR) family which is a subfamily of the seven transmembrane G protein-coupled cell surface receptor family. The encoded protein acts as a cofactor in the thrombin-mediated cleavage and activation of the protease-activated receptor family member PAR4. The encoded protein plays an essential role in hemostasis and thrombosis. Alternate splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Feb 2012],Function:
function:Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis.,PTM:A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with INSC/inscuteable and probably GPSM2.,tissue specificity:Highest expression in the megakaryocytes of the bone marrow, lower in mature megakaryocytes, in platelets and in a variety of other tissues such as heart and gut.,Subcellular Location:
extracellular region,plasma membrane,integral component of plasma membrane,integral component of membrane,apical plasma membrane,Expression:
G-protein coupled receptors,Human retina
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