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PAF-R Polyclonal Antibody
Datasheet
Catalog Number:
E20-73566Amount:
100ulSwiss-Prot No.:
P25105Molecular Weight:
39.2kdApplications:
IF/ICC,ELISAReactivity:
Human,Mouse,RatPurification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human PTAFR. AA range:194-243Specificity/Sensitivity:
PAF-R Polyclonal Antibody detects endogenous levels of PAF-R protein.Storage/Stability:
-20°C/1 yearSource:
RabbitGene Name:
PTAFRDilution:
Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
- Immunofluorescence analysis of LOVO cells, using PTAFR Antibody. The picture on the right is blocked with the synthesized peptide.
Background:
platelet activating factor receptor(PTAFR) Homo sapiens This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011],Gene ID:
5724Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azideFunction:
Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.,induction:By granulocyte macrophage colony-stimulating factor (GM-CSF), interleukin-5 and n-butyrate.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed in the placenta, lung, left and rightheart ventricles, heart atrium, leukocytes and differentiated HL-60 granulocytes.,
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