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Cell Signal Transduction Research Antibodies
p57 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight32177Da
Protein NameCyclin-dependent kinase inhibitor 1C
Human Gene Id1028
Human Swiss Prot NoP49918
Mouse Swiss Prot NoP49919
Specificityp57 Polyclonal Antibody detects endogenous levels of p57 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCDKN1C; KIP2; Cyclin-dependent kinase inhibitor 1C; Cyclin-dependent kinase inhibitor p57; p57Kip2
Observed Band(KD)32
Functiondisease:Defects in CDKN1C are a cause of Beckwith-Wiedemann syndrome (BWS) [MIM:130650]. BWS is a genetically heterogeneous disorder characterized by anterior abdominal wall defects including exomphalos (omphalocele), pre- and postnatal overgrowth, and macroglossia. Additional less frequent complications include specific developmental defects and a predisposition to embryonal tumors.,disease:Defects in CDKN1C are involved in tumor formation.,function:Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.,similarity:Belongs to the CDI family.,tissue specificity:Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. High levels ar
Subcellular LocationNucleus .
ExpressionExpressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. Expressed in the eye. High levels are seen in the placenta while low levels are seen in the liver.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human CDKN1C. AA range:11-60
Gene NameCDKN1C
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Backgroundcyclin dependent kinase inhibitor 1C(CDKN1C) Homo sapiens This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010],
Conjugated Antibody
This product is also available conjugated. Format: E20-73545-Conjugate. Price: $485 / Size: 100μl.
E20-73545-FITC$485 / 100μlE20-73545-Biotin$485 / 100μlE20-73545-HRP$485 / 100μlE20-73545-AP$485 / 100μlE20-73545-AF350$485 / 100μlE20-73545-AF405M$485 / 100μlE20-73545-AF488$485 / 100μlE20-73545-AF514$485 / 100μlE20-73545-AF532$485 / 100μlE20-73545-AF555$485 / 100μlE20-73545-AF568$485 / 100μlE20-73545-AF405S$485 / 100μlE20-73545-AF405L$485 / 100μlE20-73545-AF546$485 / 100μlE20-73545-AF594$485 / 100μlE20-73545-AF610$485 / 100μlE20-73545-AF635$485 / 100μlE20-73545-AF647$485 / 100μlE20-73545-AF680$485 / 100μlE20-73545-AF700$485 / 100μlE20-73545-AF750$485 / 100μlE20-73545-AF790$485 / 100μlE20-73545-APC$485 / 100μlE20-73545-PE$485 / 100μlE20-73545-Cy3$485 / 100μlE20-73545-Cy5$485 / 100μlE20-73545-Cy5.5$485 / 100μlE20-73545-Cy7$485 / 100μlE20-73545-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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