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Cell Signal Transduction Research Antibodies
p53RFP Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight40737Da
Protein NameRibonucleoside-diphosphate reductase subunit M2 B
Human Gene Id50484
Human Swiss Prot NoQ7LG56
Mouse Gene Id382985
Mouse Swiss Prot NoQ6PEE3
Specificityp53R2 Polyclonal Antibody detects endogenous levels of p53R2 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameRRM2B; P53R2; Ribonucleoside-diphosphate reductase subunit M2 B; TP53-inducible ribonucleotide reductase M2 B; p53-inducible ribonucleotide reductase small subunit 2-like protein; p53R2
Observed Band(KD)40
Functioncatalytic activity:2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H(2)O = ribonucleoside diphosphate + thioredoxin.,cofactor:Binds 2 iron ions per subunit.,disease:Defects in RRM2B are the cause of encephalomyopathic mitochondrial depletion syndrome with renal tubulopathy (EMDSRT) [MIM:612075]. Mitochondrial DNA depletion syndrome (MDS) is a clinically heterogeneous group of disorders characterized by a reduction in mitochondrial DNA (mtDNA) copy number. The encephalomyopathic form with renal tubulopathy is presented with various combinations of hypotonia, tubulopathy, seizures, respiratory distress, diarrhea, and lactic acidosis.,function:Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis
Subcellular LocationCytoplasm. Nucleus. Translocates from cytoplasm to nucleus in response to DNA damage.
ExpressionWidely expressed at a high level in skeletal muscle and at a weak level in thymus. Expressed in epithelial dysplasias and squamous cell carcinoma.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenSynthesized peptide derived from the Internal region of human p53R2.
Gene NameRRM2B
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Backgroundribonucleotide reductase regulatory TP53 inducible subunit M2B(RRM2B) Homo sapiens This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010],
Conjugated Antibody
This product is also available conjugated. Format: E20-73543-Conjugate. Price: $485 / Size: 100μl.
E20-73543-FITC$485 / 100μlE20-73543-Biotin$485 / 100μlE20-73543-HRP$485 / 100μlE20-73543-AP$485 / 100μlE20-73543-AF350$485 / 100μlE20-73543-AF405M$485 / 100μlE20-73543-AF488$485 / 100μlE20-73543-AF514$485 / 100μlE20-73543-AF532$485 / 100μlE20-73543-AF555$485 / 100μlE20-73543-AF568$485 / 100μlE20-73543-AF405S$485 / 100μlE20-73543-AF405L$485 / 100μlE20-73543-AF546$485 / 100μlE20-73543-AF594$485 / 100μlE20-73543-AF610$485 / 100μlE20-73543-AF635$485 / 100μlE20-73543-AF647$485 / 100μlE20-73543-AF680$485 / 100μlE20-73543-AF700$485 / 100μlE20-73543-AF750$485 / 100μlE20-73543-AF790$485 / 100μlE20-73543-APC$485 / 100μlE20-73543-PE$485 / 100μlE20-73543-Cy3$485 / 100μlE20-73543-Cy5$485 / 100μlE20-73543-Cy5.5$485 / 100μlE20-73543-Cy7$485 / 100μlE20-73543-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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