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Cell Signal Transduction Research Antibodies
p38 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight41293Da
Protein NameMitogen-activated protein kinase 14
Human Gene Id1432
Human Swiss Prot NoQ16539
Mouse Gene Id26416
Mouse Swiss Prot NoP47811
Rat Swiss Prot NoP70618
Specificityp38 Polyclonal Antibody detects endogenous levels of p38 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameMAPK14; CSBP; CSBP1; CSBP2; CSPB1; MXI2; SAPK2A; Mitogen-activated protein kinase 14; MAP kinase 14; MAPK 14; Cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAP kinase MXI2; MAX-interacting protein
Observed Band(KD)38
Functioncatalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,domain:The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.,enzyme regulation:Activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases, MAP2K3 or MAP2K6, and potentially also MAP2K4. Inhibited by dual specificity phosphatases, such as DUSP1. Specifically inhibited by the binding of pyridinyl-imidazole compounds, which are cytokine-suppressive anti-inflammatory drugs (CSAID). Isoform Mxi2 is 100-fold less sensitive to these agents than the other isoforms and is not inhibited by DUSP1. Isoform Exip is not activated by MAP2K6.,function:Responds to activation by environmental stress, pro-inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and seve
Subcellular LocationCytoplasm . Nucleus .
ExpressionBrain, heart, placenta, pancreas and skeletal muscle. Expressed to a lesser extent in lung, liver and kidney.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human p38 MAPK. AA range:288-337
Gene NameMAPK14
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Backgroundmitogen-activated protein kinase 14(MAPK14) Homo sapiens The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding d
Conjugated Antibody
This product is also available conjugated. Format: E20-73514-Conjugate. Price: $485 / Size: 100μl.
E20-73514-FITC$485 / 100μlE20-73514-Biotin$485 / 100μlE20-73514-HRP$485 / 100μlE20-73514-AP$485 / 100μlE20-73514-AF350$485 / 100μlE20-73514-AF405M$485 / 100μlE20-73514-AF488$485 / 100μlE20-73514-AF514$485 / 100μlE20-73514-AF532$485 / 100μlE20-73514-AF555$485 / 100μlE20-73514-AF568$485 / 100μlE20-73514-AF405S$485 / 100μlE20-73514-AF405L$485 / 100μlE20-73514-AF546$485 / 100μlE20-73514-AF594$485 / 100μlE20-73514-AF610$485 / 100μlE20-73514-AF635$485 / 100μlE20-73514-AF647$485 / 100μlE20-73514-AF680$485 / 100μlE20-73514-AF700$485 / 100μlE20-73514-AF750$485 / 100μlE20-73514-AF790$485 / 100μlE20-73514-APC$485 / 100μlE20-73514-PE$485 / 100μlE20-73514-Cy3$485 / 100μlE20-73514-Cy5$485 / 100μlE20-73514-Cy5.5$485 / 100μlE20-73514-Cy7$485 / 100μlE20-73514-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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