Product Information
Molecular Weight17700 Da
Protein NameCyclin-dependent kinase 4 inhibitor D
Human Gene Id1032
Human Swiss Prot NoP55273
Mouse Swiss Prot NoQ60773
Specificityp19 Polyclonal Antibody detects endogenous levels of p19 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCDKN2D; Cyclin-dependent kinase 4 inhibitor D; p19-INK4d
Functionfunction:Interacts strongly with CDK4 and CDK6 and inhibits them.,similarity:Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.,similarity:Contains 4 ANK repeats.,
Subcellular Locationnucleus,nucleoplasm,cytoplasm,cytosol,cyclin D2-CDK4 complex,
ExpressionBone marrow,Muscle,Platelet,Thymus,
Backgroundcyclin dependent kinase inhibitor 2D(CDKN2D) Homo sapiens The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008],