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Cell Signal Transduction Research Antibodies
p18 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight18127Da
Protein NameCyclin-dependent kinase 4 inhibitor C
Human Gene Id1031
Human Swiss Prot NoP42773
Mouse Gene Id12580
Mouse Swiss Prot NoQ60772
Specificityp18 Polyclonal Antibody detects endogenous levels of p18 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCDKN2C; CDKN6; Cyclin-dependent kinase 4 inhibitor C; Cyclin-dependent kinase 6 inhibitor; p18-INK4c; p18-INK6
Observed Band(KD)18
Functiondisease:Defects in CDKN2C are involved in tumor formation.,function:Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.,similarity:Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.,similarity:Contains 4 ANK repeats.,subunit:Heterodimer of p18 with CDK6.,tissue specificity:Highest levels found in skeletal muscle. Also found in pancreas and heart.,
Subcellular Locationnucleus,cytoplasm,cytosol,
ExpressionHighest levels found in skeletal muscle. Also found in pancreas and heart.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human p18 INK. AA range:111-160
Gene NameCDKN2C
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Backgroundcyclin dependent kinase inhibitor 2C(CDKN2C) Homo sapiens The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-73495-Conjugate. Price: $485 / Size: 100μl.
E20-73495-FITC$485 / 100μlE20-73495-Biotin$485 / 100μlE20-73495-HRP$485 / 100μlE20-73495-AP$485 / 100μlE20-73495-AF350$485 / 100μlE20-73495-AF405M$485 / 100μlE20-73495-AF488$485 / 100μlE20-73495-AF514$485 / 100μlE20-73495-AF532$485 / 100μlE20-73495-AF555$485 / 100μlE20-73495-AF568$485 / 100μlE20-73495-AF405S$485 / 100μlE20-73495-AF405L$485 / 100μlE20-73495-AF546$485 / 100μlE20-73495-AF594$485 / 100μlE20-73495-AF610$485 / 100μlE20-73495-AF635$485 / 100μlE20-73495-AF647$485 / 100μlE20-73495-AF680$485 / 100μlE20-73495-AF700$485 / 100μlE20-73495-AF750$485 / 100μlE20-73495-AF790$485 / 100μlE20-73495-APC$485 / 100μlE20-73495-PE$485 / 100μlE20-73495-Cy3$485 / 100μlE20-73495-Cy5$485 / 100μlE20-73495-Cy5.5$485 / 100μlE20-73495-Cy7$485 / 100μlE20-73495-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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