p15 Polyclonal Antibody

Name: p15 Polyclonal Antibody
Brand: EnoGene Biotech Co. Ltd
SKU: E20-73492
Price: 225 USD
Availability: InStock

E20-73492Cite ID: EN0053625Datasheet COA MSDS

SourcePolyclonal, Rabbit

$225/ 100ul

Quantity

Total: $225

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

OverviewImages & Data (2)Documents

Product Information

Molecular Weight14722Da

Protein NameCyclin-dependent kinase 4 inhibitor B

Human Gene Id1030

Human Swiss Prot NoP42772

Mouse Gene Id12579

Mouse Swiss Prot NoP55271

Rat Gene Id25164

Rat Swiss Prot NoP55272

Specificityp15 Polyclonal Antibody detects endogenous levels of p15 protein.

FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration1 mg/ml

Storage Stability-20°C/1 year

Other NameCDKN2B; MTS2; Cyclin-dependent kinase 4 inhibitor B; Multiple tumor suppressor 2; MTS-2; p14-INK4b; p15-INK4b; p15INK4B

Observed Band(KD)14

Functiondisease:Defects in CDKN2B are involved in tumor formation.,function:Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.,polymorphism:Genetic variations in CDKN2B may underlie susceptibility to uveal melanoma [MIM:155720]. Uveal melanoma is the most common type of ocular malignant tumor, consisting of overgrowth of uveal melanocytes and often preceded by a uveal nevus.,similarity:Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.,similarity:Contains 4 ANK repeats.,subunit:Heterodimer of CDKN2B with CDK4 or CDK6.,

Subcellular LocationCytoplasm . Also found in the nucleus.

ExpressionIsoform 2 is expressed in normal (keratinocytes, fibroblasts) and tumor cell lines.

PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

ImmunogenThe antiserum was produced against synthesized peptide derived from human p15 INK. AA range:89-138

Gene NameCDKN2B

DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.

Backgroundcyclin dependent kinase inhibitor 2B(CDKN2B) Homo sapiens This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008],

📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Lot-specific COA (generated from product data)🧪MSDS
Material safety data sheet (generated)

Conjugated Antibody

This product is also available conjugated. Format: E20-73492-Conjugate. Price: $485 / Size: 100μl.

E20-73492-FITC$485 / 100μlE20-73492-Biotin$485 / 100μlE20-73492-HRP$485 / 100μlE20-73492-AP$485 / 100μlE20-73492-AF350$485 / 100μlE20-73492-AF405M$485 / 100μlE20-73492-AF488$485 / 100μlE20-73492-AF514$485 / 100μlE20-73492-AF532$485 / 100μlE20-73492-AF555$485 / 100μlE20-73492-AF568$485 / 100μlE20-73492-AF405S$485 / 100μlE20-73492-AF405L$485 / 100μlE20-73492-AF546$485 / 100μlE20-73492-AF594$485 / 100μlE20-73492-AF610$485 / 100μlE20-73492-AF635$485 / 100μlE20-73492-AF647$485 / 100μlE20-73492-AF680$485 / 100μlE20-73492-AF700$485 / 100μlE20-73492-AF750$485 / 100μlE20-73492-AF790$485 / 100μlE20-73492-APC$485 / 100μlE20-73492-PE$485 / 100μlE20-73492-Cy3$485 / 100μlE20-73492-Cy5$485 / 100μlE20-73492-Cy5.5$485 / 100μlE20-73492-Cy7$485 / 100μlE20-73492-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.