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Cell Signal Transduction Research Antibodies
p140Cap Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight112466Da
Protein NameSRC kinase signaling inhibitor 1
Human Gene Id80725
Human Swiss Prot NoQ9C0H9
Mouse Gene Id56013
Mouse Swiss Prot NoQ9QWI6
Rat Gene Id56029
Rat Swiss Prot NoQ9QXY2
Specificityp140Cap Polyclonal Antibody detects endogenous levels of p140Cap protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameSRCIN1; KIAA1684; P140; SRC kinase signaling inhibitor 1; SNAP-25-interacting protein; SNIP; p130Cas-associated protein; p140Cap
Observed Band(KD)112
Functionfunction:Delays the onset of cell spreading in the early stages of cell adhesion to fibronectin. Also involved in calcium-dependent exocytosis from PC12 cells.,PTM:Tyrosine-phosphorylated in response to EGF and to cell adhesion to integrin ligands.,similarity:Belongs to the p140Cap family.,subcellular location:Localized to the perinuclear region, lamellopodia, cortical actin and actin stress fibers but not to focal adhesions.,subunit:Interacts with the N-terminal coiled-coil region of SNAP25 (By similarity). Interacts with BCAR1/p130Cas through its C-terminal domain.,
Subcellular LocationCytoplasm . Cytoplasm, cytoskeleton . Cell projection, axon . Cell projection, dendrite . Cell junction, synapse, presynapse . Cell junction, synapse, postsynapse . Cell junction, synapse, postsynaptic density . Localized to the perinuclear region, lamellopodia, cortical actin and actin stress fibers but not to focal adhesions. Strongly expressed in axons and dendrites of the CA1 and CA3 hippocampal regions and of the dentate gyrus. Detected in both presynapses and postsynapses and enriched in postsynaptic density fractions. .
ExpressionExpressed in some primary breast carcinomas where its presence is significantly associated with increased tumor size. Not detected in normal breast tissue.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human SNIP. AA range:811-860
Gene NameSRCIN1
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Backgroundfunction:Delays the onset of cell spreading in the early stages of cell adhesion to fibronectin. Also involved in calcium-dependent exocytosis from PC12 cells.,PTM:Tyrosine-phosphorylated in response to EGF and to cell adhesion to integrin ligands.,similarity:Belongs to the p140Cap family.,subcellular location:Localized to the perinuclear region, lamellopodia, cortical actin and actin stress fibers but not to focal adhesions.,subunit:Interacts with the N-terminal coiled-coil region of SNAP25 (By similarity). Interacts with BCAR1/p130Cas through its C-terminal domain.,
Conjugated Antibody
This product is also available conjugated. Format: E20-73491-Conjugate. Price: $485 / Size: 100μl.
E20-73491-FITC$485 / 100μlE20-73491-Biotin$485 / 100μlE20-73491-HRP$485 / 100μlE20-73491-AP$485 / 100μlE20-73491-AF350$485 / 100μlE20-73491-AF405M$485 / 100μlE20-73491-AF488$485 / 100μlE20-73491-AF514$485 / 100μlE20-73491-AF532$485 / 100μlE20-73491-AF555$485 / 100μlE20-73491-AF568$485 / 100μlE20-73491-AF405S$485 / 100μlE20-73491-AF405L$485 / 100μlE20-73491-AF546$485 / 100μlE20-73491-AF594$485 / 100μlE20-73491-AF610$485 / 100μlE20-73491-AF635$485 / 100μlE20-73491-AF647$485 / 100μlE20-73491-AF680$485 / 100μlE20-73491-AF700$485 / 100μlE20-73491-AF750$485 / 100μlE20-73491-AF790$485 / 100μlE20-73491-APC$485 / 100μlE20-73491-PE$485 / 100μlE20-73491-Cy3$485 / 100μlE20-73491-Cy5$485 / 100μlE20-73491-Cy5.5$485 / 100μlE20-73491-Cy7$485 / 100μlE20-73491-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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