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p130 Cas Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-73488

  • Amount:

    100ul

  • Molecular Weight:

    ： 93362Da

  • Purification:

    ： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    ： The antiserum was produced against synthesized peptide derived from human p130 Cas. AA range:131-180

  • Source:

    ： Polyclonal, Rabbit

  • Western Blot analysis of various cells using p130 Cas Polyclonal Antibody

  • Gene Name:

    ： BCAR1

  • Dilution:

    ： Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

  • Protein Name:

    ： Breast cancer anti-estrogen resistance protein 1

  • Human Gene Id:

    ： 9564

  • Human Swiss Prot No:

    ： P56945

  • Mouse Gene Id:

    ： 12927

  • Mouse Swiss Prot No:

    ： Q61140

  • Rat Gene Id:

    ： 25414

  • Rat Swiss Prot No:

    ： Q63767

  • Specificity:

    ： p130 Cas Polyclonal Antibody detects endogenous levels of p130 Cas protein.

  • Formulation:

    ： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    ： 1 mg/ml

  • Storage Stability:

    ： -20°C/1 year

  • Other Name:

    ： BCAR1; CAS; CASS1; CRKAS; Breast cancer anti-estrogen resistance protein 1; CRK-associated substrate; Cas scaffolding protein family member 1; p130cas

  • Observed Band(KD):

    ： 130

  • Background:

    ： BCAR1, Cas family scaffolding protein(BCAR1) Homo sapiens BCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events, including migration, survival, transformation, and invasion (Sawada et al., 2006 [PubMed 17129785]).[supplied by OMIM, May 2009],

  • Function:

    ： domain:A serine-rich region promotes activation of the serum response element (SRE).,domain:Contains a central domain (substrate domain) containing multiple potential SH2-binding sites and a C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK, NCK and ABL SH2 domains. The HLH motif is absolutely required for the induction of pseudohyphal growth in yeast and mediates heterodimerization with CASL.,domain:The SH3 domain is necessary for the localization of the protein to focal adhesions and interacts with one proline-rich region of focal adhesion kinase 1.,function:Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.,PTM:Focal adhesion kinase 1 phosphoryl

  • Subcellular Location:

    ： Cell junction, focal adhesion . Cytoplasm . Cell projection, axon . Unphosphorylated form localizes in the cytoplasm (By similarity). Localizes to focal adhesion sites following integrin engagement (By similarity). .

  • Expression:

    ： Widely expressed with an abundant expression in the testis. Low level of expression seen in the liver, thymus, and peripheral blood leukocytes. The protein has been detected in a B-cell line.

  • Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using p130 Cas Antibody. The picture on the right is blocked with the synthesized peptide.

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Catalog Number

  • Amount:100ul
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p130 Cas Polyclonal Antibody | EnoGene Biotech Co. Ltd